为什么我们无法“治愈”癌症?
字幕摘录
| 时间 | 英文 | 中文 |
|---|---|---|
| 0:00 | Yes, we can't cure cancer, not now, probably not in your lifetime, and the reason has nothing | 是的,我们无法治愈癌症,不是现在, 可能不会在你生命中, |
| 0:07 | to do with money or willpower. | 钱或意志力 |
| 0:09 | The pitch you've heard for 50 years, cancer is one breakthrough away, AI plus CRISPR plus | 50年来你听到的 癌症是一个突破 AI加CRISPR加 |
| 0:16 | mRNA equals a finish line, runs on a category error. | mRNA等于一个终点,运行在分类错误上. |
| 0:21 | Cancer isn't a disease you cure, it is evolution by natural selection running inside your body | 癌症不是你治愈的疾病,而是通过自然选择在身体里进行进化 |
| 0:28 | on Fast Forward. | 在快速前进。 |
| 0:29 | Every treatment that kills 99% of the cancer breeds the 1% that survive. | 每一次杀死99%的癌症的治疗 都会产生1%的存活率。 |
| 0:36 | In 1971, Richard Nixon signed the National Cancer Act and called it a moonshot, with | 1971年,理查德·尼克松签署"国家癌症法案",并称其为"月光照",与"N. |
| 0:43 | advocates promising meaningful progress by the American Bicentennial. | 主张美国二百周年取得有意义的进展。 |
| 0:47 | 55 years and roughly $200 billion of public funding later, pancreatic cancer's five-year | 55年后 大约2000亿美元的公共资金 胰腺癌五年 |
展开字幕全文(246 条)
| 序号 | 英文 | 中文 |
|---|---|---|
| 1 | Yes, we can't cure cancer, not now, probably not in your lifetime, and the reason has nothing | 是的,我们无法治愈癌症,不是现在, 可能不会在你生命中, |
| 2 | to do with money or willpower. | 钱或意志力 |
| 3 | The pitch you've heard for 50 years, cancer is one breakthrough away, AI plus CRISPR plus | 50年来你听到的 癌症是一个突破 AI加CRISPR加 |
| 4 | mRNA equals a finish line, runs on a category error. | mRNA等于一个终点,运行在分类错误上. |
| 5 | Cancer isn't a disease you cure, it is evolution by natural selection running inside your body | 癌症不是你治愈的疾病,而是通过自然选择在身体里进行进化 |
| 6 | on Fast Forward. | 在快速前进。 |
| 7 | Every treatment that kills 99% of the cancer breeds the 1% that survive. | 每一次杀死99%的癌症的治疗 都会产生1%的存活率。 |
| 8 | In 1971, Richard Nixon signed the National Cancer Act and called it a moonshot, with | 1971年,理查德·尼克松签署"国家癌症法案",并称其为"月光照",与"N. |
| 9 | advocates promising meaningful progress by the American Bicentennial. | 主张美国二百周年取得有意义的进展。 |
| 10 | 55 years and roughly $200 billion of public funding later, pancreatic cancer's five-year | 55年后 大约2000亿美元的公共资金 胰腺癌五年 |
| 11 | survival rate sits at 13%. | 存活率为13%。 |
| 12 | The reason isn't that we're behind, it's that we've been fighting the wrong shape of the problem. | 原因并不是我们落后,而是我们一直在与问题的错误形态作斗争. |
| 13 | Start with the word itself, cancer, singular, as if naming it makes it one thing, it isn't. | 从这个词本身开始, 癌症,单数, 仿佛命名它使它 一件事情,它不是。 |
| 14 | The word covers something like 200 distinct diseases that share exactly one trait, cells | 这个词覆盖了200种不同的疾病 有着一个特征,细胞 |
| 15 | multiplying, when they shouldn't. | 乘,当不应. |
| 16 | That is the entire common feature, beyond that, the cancer in a smoker's lung and the cancer | 这是整个共同的特征, 除此之外, 癌症在吸烟者的肺和癌症 |
| 17 | in a child's bone marrow have less in common, biologically, than a hummingbird and a shark. | 与蜂鸟和鲨鱼相比,孩子的骨髓在生物学上没有那么常见。 |
| 18 | Baird Vogelstein at John Hopkins spent the 1990s mapping what actually goes wrong inside tumors. | 约翰·霍普金斯的贝尔德·沃格尔斯坦(Baird Vogelstein) 在1990年代绘制了肿瘤内部实际出错的地图。 |
| 19 | His lab found that even a single colorectal tumor, one tumor in one person, typically | 他的实验室发现,即使是单一的直肠肿瘤, 一个人的肿瘤,通常 |
| 20 | carries between 30 and 70 distinct mutations. | 携带着30到70个不同的突变 |
| 21 | Each tumor is genetically its own snowflake. | 每一个肿瘤都是遗传性的 自己的雪花。 |
| 22 | Two patients with what the pathologist labels as Stage 3 colon cancer are often carrying | 两个病理学家称之为第三级结肠癌的病人经常携带 |
| 23 | diseases that share a name and almost nothing else. | 疾病是同一个名字,几乎没有别的。 |
| 24 | Take breast cancer, the example everyone knows. | 以乳腺癌为例,大家都知道 |
| 25 | The pathologist's label hides at least four molecularly different illnesses, Luminal A, | 病理学家的标签 隐藏至少四个分子不同的疾病, Luminal A, |
| 26 | Luminal B, HER2-enriched, and triple negative. | 低气压B,HER2浓缩,和三阴性。 |
| 27 | Each one responds to different drugs, has different prognosis, and is in any meaningful | 每个人对不同的药物的反应, 不同的预后,在任何有意义的 |
| 28 | sense a different disease. | 感觉一种不同的疾病。 |
| 29 | The chemotherapy that saves a HER2-positive patient does very little for triple negative. | 救出HER2-阳性病人的化疗对三阴性作用很小. |
| 30 | Same word on the chart, different biology underneath. | 图表上的同一个词, 不同的生物学下面。 |
| 31 | This is why a treatment that works miraculously for one woman with breast cancer does nothing | 这就是为什么一个乳癌女性的治疗是奇迹般的 |
| 32 | for the woman in the next room. | 给隔壁房间的女人 |
| 33 | Not because the medicine failed her, because she did not have the same disease. | 不是因为药让她失望 因为她没有同样的病 |
| 34 | And this isn't a problem clever oncology can solve. | 这不是一个聪明的肿瘤学可以解决的问题。 |
| 35 | It is a categorization mistake baked in centuries ago. | 这是几百年前发生的分类错误。 |
| 36 | We named cancers by where they started, lung and breast and pancreas, because that's all | 我们用癌症的发源地命名了 肺、乳腺和胰腺 |
| 37 | the doctors of the 1800s could see. | 1800年代的医生可以看见 |
| 38 | Modern molecular biology shows that a lung tumor with a particular mutation profile responds | 现代分子生物学显示,具有特定突变特征的肺瘤反应 |
| 39 | to drugs that work on melanoma. | 治疗黑色素瘤的药物 |
| 40 | While two lung cancers in adjacent hospital beds may need entirely different chemotherapies, | 虽然邻近医院病床上的两种肺癌可能需要完全不同的化疗, |
| 41 | the taxonomy was always a fiction. | 分类学一向是虚构的 |
| 42 | We just didn't have microscopes good enough to see through it. | 我们只是没有显微镜 足够看穿它。 |
| 43 | So the first wall is linguistic before it is biological. | 所以第一道墙在生物化之前是语言化的. |
| 44 | We say cure cancer the same way someone might say cure infection. | 我们说治愈癌症 就像有人说治愈感染一样 |
| 45 | There is no cure for infection. | 感染无法治愈。 |
| 46 | There are cures for specific infections, sometimes, when we're lucky and the pathogen cooperates. | 有治疗特定感染的药,有时, 当我们幸运,病原体合作。 |
| 47 | Cancer is the same kind of word, hiding the same kind of plurality. | 癌症是同一个词,隐藏着同样的多元性。 |
| 48 | Now the deeper trap. | 现在更深的陷阱。 |
| 49 | Peter Noel, a pathologist at the University of Pennsylvania, published a paper in Science | 宾夕法尼亚大学病理学家彼得·诺埃尔(Peter Noel)发表了一篇关于科学的论文 |
| 50 | in 1976 with a title most people have never heard, but that quietly rewrote cancer biology. | 1976年的头衔 大多数人从未听说过 但那悄悄地重温了癌症生物学 |
| 51 | The Clonal Evolution of Tumor Cell Populations. | 肿瘤细胞群的克隆进化. |
| 52 | Noel proposed something that sounds obvious in retrospect and was heretical at the time. | 诺埃尔提出一些在回顾中听起来很明显,在当时是异端的. |
| 53 | A tumor isn't a clump of identical bad cells. | 肿瘤不是一团坏细胞 |
| 54 | It is a population, a small ecosystem. | 这是一个人口,一个小的生态系统。 |
| 55 | And like any ecosystem, it evolves. | 和任何生态系统一样,它会进化。 |
| 56 | Here's the mechanism, step by step. | 这是机制 一步一步 |
| 57 | A tumor starts when one cell picks up the wrong combination of mutations | 当一个细胞发现突变的结合错误时 肿瘤就会开始 |
| 58 | and begins dividing without permission. | 并擅自开始分割 |
| 59 | As that cell divides, daughter cells accumulate new mutations of their own. | 随着细胞分裂,女儿细胞会累积他们自己的新的突变. |
| 60 | Some daughters carry changes that make them grow faster and they outcompete their cousins. | 一些女儿背负着变化,使得她们的成长速度更快,并且超越了表亲的能力. |
| 61 | Some can slip past immune surveillance. | 有些人可以滑过免疫监视 |
| 62 | And those win too. | 那些也赢了。 |
| 63 | Within a few months, what looks like a single clump under the microscope | 几个月后 显微镜下看起来像一团 |
| 64 | is actually a forest of slightly different cells, each holding a slightly different genetic hand. | 实际上是一个小不同细胞的森林, 每个细胞的基因手都有小不同。 |
| 65 | Now you walk in with chemotherapy. | 现在你走进化疗。 |
| 66 | Chemotherapy is, mechanically, a selection pressure. | 化学疗法在机械上是一种选择压力. |
| 67 | A drug that kills 99% of cancer cells | 99%的癌细胞死亡的药物 |
| 68 | leaves the 1% that happen to carry mutations conferring resistance. | 留下1% 碰巧带突变 产生阻力。 |
| 69 | Those survivors aren't damaged. | 那些幸存者没有受损。 |
| 70 | They're selected. | 他们被选中了 |
| 71 | They divide. | 他们分裂。 |
| 72 | Within months, you have a tumor naturally optimized to ignore the drug you just used. | 几个月内,你的肿瘤自然优化 以忽略你刚刚使用的药物。 |
| 73 | This isn't a failure of medicine. | 这不是医学的失败。 |
| 74 | It is natural selection doing exactly what it always does, | 这是自然选择 做它总是做的, |
| 75 | just inside a human on the time scale of a single TV season. | 仅仅在人类体内 时间尺度 一个单一的电视季。 |
| 76 | Charles Darwin would have recognized this immediately. | 查尔斯·达尔文会立刻认出来的 |
| 77 | Cancer cells or organisms competing in an environment, | 癌症细胞或生物在环境中竞争, |
| 78 | your body, reproducing with variation, | 你的身体,以变异的方式复制, |
| 79 | and being selected for traits that help them survive. | 并被选为能帮助他们生存的特质。 |
| 80 | The fact that this evolution is killing the host is just bad luck for the host. | 这种进化正在杀死宿主的事实对宿主来说只是运气不好. |
| 81 | The cancer doesn't care. | 癌症不关心。 |
| 82 | It can't care. | 它不能关心。 |
| 83 | Evolution does not have a plan beyond the next generation. | 进化没有超越下一代的计划. |
| 84 | Carlo Maley at Arizona State University has spent his career arguing that | 亚利桑那州立大学的Carlo Maley 在他的职业生涯中一直认为 |
| 85 | the dream of curing cancer is incoherent for this exact reason. | 治疗癌症的梦想是不一致的 正是因为这个原因 |
| 86 | You can slow evolution and sometimes redirect it. | 你可以放慢进化速度,有时也会改变进化方向. |
| 87 | You can occasionally corner a tumor into a genetic dead end. | 你偶尔可以把肿瘤 变成基因死角 |
| 88 | What you can't do is cure evolution itself. | 你不能做的是 治疗进化本身。 |
| 89 | Because the same process that produced humans over 4 billion years | 因为40亿年来人类的诞生过程 |
| 90 | is what's running inside the tumor. | 是肿瘤里面流着的东西 |
| 91 | Asking medicine to permanently outsmart natural selection | 要求医学永远超越自然选择 |
| 92 | is asking it to win a chess game where the opponent gets a new piece every move. | 要求它赢得一场棋局 对手每一步都得到新棋子 |
| 93 | And the move is fast. | 而动则速. |
| 94 | In a metastatic tumor, hundreds of millions of cells divide each day. | 在一个元瘤中,每天有数亿个细胞分裂. |
| 95 | Each division is a potential roll of the dice toward resistance. | 每一个师都可能是一圈 骰子对抵抗。 |
| 96 | By the time a doctor sees an MRI showing the cancer has come back, | 当医生看到核磁共振显示癌症已复发 |
| 97 | the genome of those cells has often shifted in ways the original biopsy could not predict. | 这些细胞的基因组经常以最初的活检无法预测的方式转移。 |
| 98 | The tumor that returns is not the tumor that was treated. | 返回的肿瘤不是治疗过的肿瘤。 |
| 99 | It's the tumor's grandchild with grievances. | 是肿瘤的孙子有怨言 |
| 100 | Reason 3 sits one layer deeper. | 理由三更深一层 |
| 101 | Where most popular cancer coverage refuses to go. | 最受欢迎的癌症保险拒绝去的地方. |
| 102 | Cancer isn't an invader. | 癌症不是入侵者。 |
| 103 | It isn't a virus you can catch or a bacterium you can sterilize. | 它不是一个病毒 你可以捕捉 或细菌 你可以绝育。 |
| 104 | Cancer is your own cells doing what cells do, going slightly wrong. | 癌症是你自己的细胞 做细胞做, 略有错误。 |
| 105 | And the going slightly wrong isn't a malfunction. | 发生小错误不是故障 |
| 106 | It is statistically guaranteed. | 从统计学上说,这是有保障的。 |
| 107 | Here's the math. | 这里的数学。 |
| 108 | Your body contains roughly 37 trillion cells. | 你的身体含有大约37万亿细胞。 |
| 109 | An estimate worked out by the Italian biophysicist Eva Bianconi in 2013. | 意大利生物物理学家伊娃·比安科尼在2013年所作的估计. |
| 110 | Most of those cells divide regularly. | 这些细胞大多经常分裂。 |
| 111 | Your gut lining replaces itself every few days. | 你的直肠每过几天就换衣服 |
| 112 | Your skin every month. | 你的皮肤每个月。 |
| 113 | Your blood cells constantly. | 你的血细胞不断。 |
| 114 | Every division copies about 3 billion DNA base pairs. | 每个师复制大约30亿DNA碱基对. |
| 115 | And the copying machinery is staggeringly accurate, | 而复制机械 惊人准确, |
| 116 | with an error rate somewhere around one mistake per billion bases. | 误差率大约为每十亿个基数一个误差 |
| 117 | Sounds great, until you multiply. | 听起来不错,直到你倍增。 |
| 118 | 3 billion bases times trillions of divisions times decades of life. | 30亿基数乘以万亿的分裂乘以数十年的生命. |
| 119 | The number of mutations your body accumulates by age 60 runs into the quadrillions. | 身体累积的突变数量在60岁前 进入四倍体 |
| 120 | Most do nothing. | 大多数人什么都不做。 |
| 121 | A few hit important genes. | 有几颗击中了重要的基因. |
| 122 | Eventually, the wrong combination lands in the wrong cell at the wrong time. | 最终,错误的组合在错误的时间降落在错误的细胞中. |
| 123 | And that cell becomes a cancer. | 细胞会变成癌症 |
| 124 | This is why cancer rates climb almost exponentially with age. | 这就是为什么癌症发病率几乎随年龄而成指数上升。 |
| 125 | It isn't bad luck so much as dice rolls finally hitting the wrong number after enough rolls. | 它不是坏运气 因为它的骰子滚 终于打错了号码 后足够的滚。 |
| 126 | Which raises a strange puzzle. | 这引起了一个奇怪的谜题。 |
| 127 | If cancer is a numbers game, large animals should be drowning in it. | 如果癌症是一个数字游戏,大型动物应该沉溺其中. |
| 128 | A blue whale has roughly a thousand times the cells of a human. | 蓝鲸的细胞是人类的一千倍 |
| 129 | So, by the math, a whale should carry a thousand times the cancer risk. | 所以,从数学上看,鲸鱼应该承担癌症风险的一千倍。 |
| 130 | They don't. | 他们没有。 |
| 131 | Whales and elephants get cancer at roughly the same rate we do. | 鲸和大象的癌症率和我们差不多 |
| 132 | Sometimes even less. | 有时更无. |
| 133 | This contradiction has a name. | 这个矛盾有一个名字. |
| 134 | Peto's Paradox. | 彼陀跋陀罗经. |
| 135 | After the Oxford epidemiologist Richard Peto, who pointed it out in 1977. | 在牛津流行病学家理查德·佩托(Richard Peto)于1977年指出后. |
| 136 | The answer, worked out over the last 20 years, | 答案,在过去20年中, |
| 137 | is that big, long-lived animals had to evolve better tumor suppression | 巨型长寿动物必须进化出更好的肿瘤抑制 |
| 138 | or they could not exist at scale. | 或无法在规模上存在。 |
| 139 | Elephants, in research led by Joshua Schiffman at the University of Utah, | 大象,在犹他大学的约书亚·希夫曼领导的研究中, |
| 140 | carry roughly 20 copies of the master tumor suppressor gene TP53. | 携带约20份肿瘤抑制剂主基因TP53. |
| 141 | Humans carry one. | 人类携带一个。 |
| 142 | Whales have stacked redundancies in DNA repair across multiple genes. | 鲸鱼在DNA修复中 堆积了重复 跨越多个基因。 |
| 143 | 在罗彻斯特大学 由Vera Gorbanova研究的裸鼠 | |
| 144 | produce a high molecular weight version of hyaluronic acid | 生成高分子量的hy酸 |
| 145 | that physically prevents their cells from packing densely enough to form tumors. | 能够防止细胞包裹的密度 足以形成肿瘤 |
| 146 | They are, in practice, almost cancer immune. | 在实践中,他们几乎是癌症的免疫者。 |
| 147 | You might think, fine, copy the elephants. | 你可能会想,好的,复制大象。 |
| 148 | Add more TP53. | 添加更多的TP53. |
| 149 | Make humans naked mole rat proof. | 使人类裸鼠鼠证. |
| 150 | But these adaptations are tangled into the entire genome. | 但这些适应被缠绕在整个基因组中. |
| 151 | They evolved over tens of millions of years, | 它们在几千万年里进化, |
| 152 | with side effects compensated by other mutations elsewhere. | 副作用由其他地方的其他突变补偿。 |
| 153 | You can't bolt them onto a human the way you'd add a feature to a phone. | 你不能像在手机上增加一个功能那样 把它们锁在人身上 |
| 154 | We're roughly stuck with the tumor suppression we have. | 我们被肿瘤抑制住了 |
| 155 | Plus whatever drugs can borrow from the outside. | 再加上任何药物都可以从外面借来. |
| 156 | What strikes me about this, the line that doesn't get said cleanly, | 是什么让我很惊讶, 这条线没有被说得干净, |
| 157 | is that humans are basically halfway at the ladder. | 人类基本上在梯子上 |
| 158 | Long lived enough that mutations accumulate, | 久而久之 突变积累, |
| 159 | not big enough to have evolved heavy redundancy. | 体积不够大 无法演化出大量冗余 |
| 160 | Cancer is, more or less, the bill for hitting 80 in a body engineered to last 40. | 癌症大致上是 80 个被设计成持续40年的身体。 |
| 161 | There's a constraint nobody likes to talk about, | 有限制 没有人喜欢谈论, |
| 162 | because it points out where the dream actually breaks. | 因为它指明了梦想真正破碎之处. |
| 163 | Roughly 90% of cancer deaths aren't from the original tumor. | 大约90%的癌症死亡不是来自原肿瘤。 |
| 164 | They're from metastasis. | 他们来自元代。 |
| 165 | Cells that left the primary site, traveled through blood or lymph, | 离开主场所的细胞 穿过血液或淋巴 |
| 166 | and seeded colonies in lung, liver, brain, and bone. | 在肺、肝、脑和骨骼中播种 |
| 167 | A breast tumor doesn't usually kill you. | 乳腺瘤通常不会杀了你 |
| 168 | Breast cells growing in your liver kill you. | 生长在肝脏里的乳细胞会杀了你 |
| 169 | This part of the disease, in 2026, is mostly unsolved. | 这部分病情,在2026年,大多未解决. |
| 170 | Modern oncology is genuinely good at the primary tumor. | 现代肿瘤学真正擅长初级肿瘤. |
| 171 | Surgeons can cut it out, radiation can shrink it, | 外科医生可以切断它 辐射可以缩小它 |
| 172 | and chemo or targeted drugs can knock it back. | 化疗或定点药物可以击退它。 |
| 173 | Five-year survival for early-stage localized breast cancer in the U.S. | 美国早期局部乳腺癌存活5年. |
| 174 | now sits at around 99%. | 现在占99%左右 |
| 175 | That's a real triumph. | 这是真正的胜利。 |
| 176 | And the Optimus case earns it. | 而"擎天柱案"得之. |
| 177 | The collapse comes when the cells have already left. | 当细胞已经离开时 就会崩溃 |
| 178 | Stage 4 breast cancer five-year survival drops to about 30%. | 第四期乳腺癌五年存活率下降到30%左右. |
| 179 | Pancreatic at the same stage runs 3%. | 同一阶段的胰腺素运行率为3%. |
| 180 | Lung sits around 8%. | 龙坐8%左右. |
| 181 | The numbers fall off a cliff because nothing in the toolkit | 数字从悬崖上掉下来 因为工具包里什么都没有 |
| 182 | reliably cleans up cells distributed across an entire body. | 可靠地清理分布在全身的细胞. |
| 183 | Surgery can't excise 20 organs at once. | 外科手术不能同时消耗20个器官. |
| 184 | Radiation can't dose the whole human. | 辐射不能给整个人类剂量 |
| 185 | And the chemotherapy dose required to kill every micrometastasis | 和化学疗法剂量 杀死每微米塔病 |
| 186 | would also kill the patient several times over. | 也会杀死病人几次 |
| 187 | Immunotherapy, the celebrated breakthrough of the last decade, | 免疫疗法 过去十年的突破 |
| 188 | helps roughly 20-30% of patients with certain cancer types | 帮助约20%-30%的癌症患者 |
| 189 | and barely touch as others. | 几乎不能和别人一样接触 |
| 190 | CAR-T cell therapy works almost magically for some blood cancers | CAR-T细胞疗法几乎神奇地治疗一些血癌 |
| 191 | and has spent years failing to translate to solid tumors. | 并花了多年时间 未能转化为固体肿瘤。 |
| 192 | The headlines are real, they're also narrow. | 头条是真实的,也是狭义的. |
| 193 | There's a worse layer underneath, the one oncologists call dormancy. | 下层更糟糕 一个肿瘤学家叫宿舍 |
| 194 | Riding slowly enough to evade every imaging tool we have, | 慢慢地逃过我们所有的影像工具 |
| 195 | they wake up when something we don't fully understand changes. | 他们醒来时,有些东西 我们不完全理解变化。 |
| 196 | A hormonal shift, a course of steroids, | 荷尔蒙转变 类固醇 |
| 197 | a drop in immune surveillance with age. | 免疫监控下降 随着年龄。 |
| 198 | This is why women treated successfully for breast cancer in their 40s | 这就是为什么40多岁的女性成功治疗乳腺癌 |
| 199 | sometimes recur in their 60s. | 有时在60多岁时会重演。 |
| 200 | Not new cancer, old cells, finally finishing the job. | 不是新癌症,老细胞, 终于完成了工作。 |
| 201 | There is currently no test that reliably finds these dormant cells | 目前还没有测试能够可靠地找到这些休眠细胞 |
| 202 | and no drug that reliably kills them. | 没有任何药物能可靠地杀死他们。 |
| 203 | We sit below the resolution of our best imaging | 我们坐在我们最好的影像的分辨率之下 |
| 204 | and below the threshold of our best treatments. | 并且低于我们最好的治疗标准 |
| 205 | And yes, the AI and CRISPR pitch keeps coming. | 是的,AI和CRISPR的投注 继续来。 |
| 206 | Faster sequencing, better drug design, | 更快的排序,更好的药物设计, |
| 207 | models that predict which mutation responds to which compound. | 预测哪个突变对哪个化合物的反应的模型。 |
| 208 | All real, all useful, none of it changes the underlying physics. | 所有真实的,所有有用的, 没有改变基础的物理。 |
| 209 | AI can read a tumor's genome faster than ever. | AI能够比以往更快地读取肿瘤的基因组. |
| 210 | It can't stop the tumor's genome from mutating while the AI reads. | 它无法阻止肿瘤的基因组在AI读取的同时突变. |
| 211 | The constraint isn't computational, it is biological. | 制约不是在计算 而是在生物学上 |
| 212 | So the actual ceiling becomes visible. | 因此实际的上限变得明显. |
| 213 | We can detect cancer earlier and survive primary tumors better. | 我们可以更早地检测癌症 并能更好地存活 |
| 214 | We can extend life with metastatic disease by months, sometimes years, | 我们可以延长生命 与运动性疾病 几个月,有时几年, |
| 215 | and keep moving the line. | 继续走 |
| 216 | What we cannot do is abolish it. | 我们不能做的是废除它。 |
| 217 | The framing of cure was always doing rhetorical work. | 治疗框架总是在做口头工作。 |
| 218 | Curing implies a state where the disease is gone, | 治愈意味着疾病消失的状态, |
| 219 | the way polio is gone from a vaccinated population. | 脊髓灰质炎从接种疫苗的人群中消失的方式。 |
| 220 | Cancer can't reach that state because cancer isn't a separate thing. | 癌症不能达到这种状态 因为癌症不是另外一回事 |
| 221 | It's what cells do when they're copying machinery makes the unlucky mistake. | 复制机械时的细胞会做出不吉利的错误. |
| 222 | In a body that has trillions of cells copying constantly | 在一个有数万亿细胞不断复制的身体中 |
| 223 | for decades in a long-lived animal that wants to keep being a long-lived animal. | 数十年的动物 想要成为长寿的动物 |
| 224 | Eliminating cancer means eliminating one of the basic statistical consequences | 消除癌症意味着消除一个基本统计后果 |
| 225 | of being a 37 trillion cell organism that lives to 80. | 是一个37万亿细胞生物 活到80个 |
| 226 | The thing oncologists actually pursue and rarely say out loud is more honest. | 肿瘤学家实际追求的,很少大声说出来的,更诚实. |
| 227 | Push the average age at cancer death past the average age of every other cause of death. | 将癌症死亡的平均年龄超过所有其他死亡原因的平均年龄。 |
| 228 | Make cancer a manageable late-life condition like high blood pressure. | 使癌症成为像高血压一样可控的晚年疾病. |
| 229 | Catch it early while the math still favors you. | 趁数学还有利于你 早点来 |
| 230 | Treat it long enough that something else takes the patient first. | 治疗时间足够长了,让病人先吃别的东西. |
| 231 | That is the actual plan and it isn't cure, it is containment. | 这是实际的计划,它不是治愈,而是遏制。 |
| 232 | 55 years into the war on cancer, the funding has done extraordinary things. | 在55年的癌症战争中, 资金已经做了非凡的事情。 |
| 233 | Childhood acute lymphoblastic leukemia, once a death sentence, | 儿童急性淋巴球性白血病 曾经是死刑 |
| 234 | is now survivable in over 90% of cases. | 现在,90%以上的病例是可以存活的。 |
| 235 | HPV-driven cervical cancer can, for the first time in human history, | HPV驱动的宫颈癌在人类历史上第一次可以 |
| 236 | be functionally prevented in vaccinated populations. | 在接种疫苗的人群中进行功能预防。 |
| 237 | Decades have been added to lives that would have once ended in the first round. | 数十年的生活已经增加,而这种生活本来会在第一轮中结束。 |
| 238 | None of that is nothing, it just isn't the cure that was sold. | 这些都不是什么,只是不是被卖掉的治疗方法。 |
| 239 | Cancer is the price of being a multicellular organism with cells that divide, | 癌症是细胞分裂的多细胞生物的代价 |
| 240 | paid in installments, accelerated by age, and rewritten by every drug we throw at it. | 分期付款 逐年递增 重写每一种药 |
| 241 | There is no breakthrough that closes the bill, because the bill is built into being alive. | 该法案没有突破,因为该法案是活生生的。 |
| 242 | Every cell in your body is, right now, copying itself with errors. | 你体内的每一个细胞 都带有错误 |
| 243 | And the only reason you don't have cancer is that the wrong errors haven't happened yet. | 你没有癌症的唯一原因是 错误还没有发生 |
| 244 | If you'd rather see how the rest of medicine's promises hold up under physics, | 如果你宁愿看看其他的医学承诺 如何在物理学下兑现, |
| 245 | subscribe. | 订阅。 |
| 246 | I cover what the press releases skip. | 我报道的是新闻稿所忽略的内容。 |
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