推荐微信扫码登录以获得更好的体验!另:🎉建议更新到最新版,以体验新功能!🎉 版本更新记录→

【双语音+文稿】(全面解析)酒精对大脑和身体的影响!——控糖

共 1 集

剧集目录

集标题时长
P2【双语音+文稿】(全面解析)酒精对大脑和身体的影响!——控糖27:57

P2 · 【双语音+文稿】(全面解析)酒精对大脑和身体的影响!——控糖女神:杰西·因肖斯佩 p02 英文版 (P2)

字幕摘录

时间英文中文
0:00You might have heard, and this is something that I heard when I was younger and growing up,你可能听说过,这是我听到的东西 当我年轻和长大,
0:03that actually one drink a day is good for you.其实一天喝一杯对你有好处
0:07And this was believed for a very long time.这被人们相信了很长一段时间。
0:09And I'm French.我是法国人
0:10And let me tell you, most French people still believe that.让我告诉你,大多数法国人仍然相信这一点。
0:14And it's not their fault.这不是他们的错。
0:15It's because they just don't know the latest science.因为他们不知道最新的科学
0:17And a lot of doctors don't even know the latest science either.很多医生甚至不知道最新的科学
0:20So let's talk about that.所以,让我们谈谈。
0:33Hello, angels, and welcome back to the Glucose Goddess Show.你好 天使们 欢迎回到葡萄糖女神秀
展开字幕全文(515 条)
序号英文中文
1You might have heard, and this is something that I heard when I was younger and growing up,你可能听说过,这是我听到的东西 当我年轻和长大,
2that actually one drink a day is good for you.其实一天喝一杯对你有好处
3And this was believed for a very long time.这被人们相信了很长一段时间。
4And I'm French.我是法国人
5And let me tell you, most French people still believe that.让我告诉你,大多数法国人仍然相信这一点。
6And it's not their fault.这不是他们的错。
7It's because they just don't know the latest science.因为他们不知道最新的科学
8And a lot of doctors don't even know the latest science either.很多医生甚至不知道最新的科学
9So let's talk about that.所以,让我们谈谈。
10Hello, angels, and welcome back to the Glucose Goddess Show.你好 天使们 欢迎回到葡萄糖女神秀
11I'm your host, Jessie Introspe.我是你的主持人 杰西·Introspe。
12I'm a French biochemist, and I love explaining science in a really fun way我是法国生物化学家 我喜欢用有趣的方式解释科学
13so that you can understand how your body functions.这样你才能理解你的身体如何运作。
14And today we're talking about alcohol.而今论酒.
15Very highly requested topic.要求很高的专题。
16When I give any conference or any talk, inevitably one person asks a question about alcohol.当我开任何会议或任何谈话时, 必然有人会问酗酒的问题。
17So today I'm going to show you all the science behind it.所以今天我要给你们展示所有背后的科学。
18What it does to our body, to our brain.它对我们的身体和我们的大脑有什么影响。
19Is it true that one drink a day is good for our health?一天喝一杯真的对我们的健康有好处吗?
20We're going to bust some myths.我们要打破一些神话。
21We're going to have a good time and you're going to learn so much.我们会很愉快的,你会学到很多的
22So let's get to it.故先说.
23The first thing I want to mention is if you've ever worn a continuous glucose monitor,首先我想说的是 如果你曾经穿 连续的葡萄糖监视器,
24which measures in real time your blood sugar levels, you might...即时测量你的血糖水平,你可能会...
25And if you drink alcohol, you might have noticed a strange pattern.如果你喝酒,你可能会注意到一个奇怪的模式。
26You might have noticed that when you have pasta on their own, you get a big glucose spike.你可能已经注意到,当你有 面食自己, 你得到一个很大的葡萄糖钉。
27But if you add, like in this graph, a glass of red wine to the pasta,但如果你像这张图一样 给面条加一杯红酒
28all of a sudden smaller glucose spike.突然间小点的葡萄糖尖刺
29Oh, my God, what is happening?哦,我的上帝,发生了什么事?
30What does this mean?这是什么意思?
31Does this mean that we should add wine to our meals to reduce the glucose spike这是否意味着我们应该把酒加进我们的饭里 以减少葡萄糖的升降
32because we know that smaller glucose spikes are better for us?因为我们知道小点的葡萄糖 对我们更好?
33No, I'm going to explain everything.不,我要解释一切
34But no, the answer is not to add wine to every single one of your meals.但是,不,答案不是在你的每餐中添加葡萄酒。
35So before we get into that, let's rewind just one second.所以,在我们进入这个之前, 让我们只倒带一秒钟。
36A drink of alcohol, whether it's wine, vodka, beer, is mostly water, about 80 to 90 percent water.一杯酒,无论是酒,伏特加酒,啤酒,都是水,大约80%到90%的水.
37Then it's ethanol, very important molecule.然后是乙醇,非常重要的分子.
38And then you have things like compounds that influence flavor.然后,你有类似化合物的东西 影响风味。
39And then in some sweet wines, you'll have really high sugar content, too.在甜酒里,你也会有很高的糖含量。
40But ethanol, the second thing I mentioned, ethanol is a molecule we're really interested in但乙醇,我提到的第二件事,乙醇是一个分子,我们真的感兴趣
41because that is the molecule that is going to have effects on our body.因为那是对我们的身体有影响的分子。
42The water and the flavor compounds, not so many effects.水和口味的化合物,没有那么多效果。
43The ethanol, lots of effects, my dear.乙醇,很多效果,亲爱的。
44So how is ethanol produced?那么乙醇是如何生产的?
45Ethanol is produced when yeast ferments the sugar in grapes or other plants当酵母在葡萄或其他植物中发酵时,会生成乙醇
46during the fermentation process for various alcohols.在各种酒精的发酵过程中。
47And just for fun, I pulled the number of ethanol molecules in a glass of wine为了好玩,我把乙醇分子 放在酒杯里
48because that's the kind of stuff I love.因为我喜欢这样
49So there are 10 to the power 23, so 10 with 23 more zeros behind it,因此,有10到电23, 所以10,还有23个零后面,
50ethanol molecules in one glass of wine.一杯酒中的乙醇分子.
51That is, fun fact, as many molecules as there are stars in the universe.这是有趣的事实, 和宇宙中恒星一样多的分子。
52Now, you know, fun fact.现在,你知道,有趣的事实。
53So in terms of the percent alcohol, if you're an alcohol drinker, you might know this,所以,从酒精的百分比来看, 如果你是一个酗酒者, 你可能知道这一点,
54but beer contains 1 percent to 6 percent ethanol.但啤酒含有1%到6%的乙醇。
55Wine is 12 to 14 percent ethanol.葡萄酒的乙醇含量为12%至14%.
56Fortified wines like cherry and port contain 18 to 20 percent ethanol.樱桃和港口等强化酒含有18%至20%的乙醇.
57And then spirits, the vodka, rums and gins are 40 to 50 percent.然后精神,伏特加,朗姆酒和杜松子酒是40%到50%。
58So what happens exactly when we drink ethanol?我们喝乙醇时会发生什么?
59I think that's the main question that we're all asking ourselves.我想这是我们自问的主要问题。
60So let's look at what happens inside our body.让我们看看我们身体里发生了什么
61As soon as we drink alcohol, it goes to our stomach and to our upper intestine,我们一喝酒,就到胃和上肠
62which is where anything that we eat or drink goes.我们吃喝的东西都在那里
63From there, the ethanol goes into our bloodstream.从那里,乙醇进入我们的血液。
64And then it is recognized by our body as a toxin.然后它被我们的身体视为一种毒素。
65It is kind of like a poison, essentially.它有点像毒药,本质上。
66It's something that our body wants to get rid of.这是我们身体想要摆脱的
67Therefore, our body sends this ethanol to our liver.因此,我们的身体将这种乙醇送入我们的肝脏。
68Why the liver?为什么是肝脏?
69Because our liver is the filtration system of our body.因为我们的肝脏是我们身体的过滤系统.
70It has a lot of work to do, especially if you drink a lot of alcohol.它有很多工作要做,特别是如果你喝了很多酒。
71And that's why you might have heard, you know, a correlation between liver problems这就是为什么你可能会听到, 你知道,肝脏问题之间的关联
72and drinking alcohol.并饮酒。
73It's because our liver has a lot to do to get rid of this toxin.因为我们的肝脏有很多事要做 才能消除这种毒素
74So what does our liver exactly do to get rid of this ethanol toxin?那么我们的肝脏究竟做了些什么来消除这种乙醇毒素?
75Well, it's kind of like, you know, when you have a big cardboard box in your house,嗯,这有点像,你知道, 当你有一个大的纸板盒 在你的房子,
76like you bought something and it came in like a massive box.就像你买了些东西, 它进来像一个巨大的盒子。
77And then you're like, oh, man, I have to get rid of this box.然后,你喜欢,哦,伙计, 我必须摆脱这个盒子。
78Well, what do you do?那么,你是做什么的? 怎么样?
79You cut the box into small pieces and then you fold the pieces and you put them in the bin.你把盒子切成小块,然后把碎片叠起来放进垃圾箱。
80Well, your liver kind of does the same thing with ethanol.你的肝脏也和乙醇一样
81It essentially tries to cut it down into smaller pieces.它基本上试图把它切成小块。
82The first thing that it cuts ethanol into is a substance called acetyl aldehyde.首先它把乙醇切成乙醇,是一种叫做乙酰甲醛的物质.
83And now for sure, you've come across this substance because it is what gives people肯定的,你已经发现了这种物质 因为它给了人们
84who drink alcohol that smell.谁喝酒精的味道。
85You know, you can smell on someone that they've had a lot to drink.你知道,你可以在某人身上闻到 他们喝了很多。
86That smell is acetyl aldehyde.这味道是乙酰乙醛
87So the first thing your liver does is to break down ethanol into acetyl aldehyde.因此,你的肝脏首先要做的是将乙醇分解为乙酰甲醛.
88The problem is, acetyl aldehyde is also very toxic for the body.问题是,乙酰甲醛对身体也具有很高的毒性.
89And then your liver has to do another thing.然后肝脏又得做别的事
90Poor liver.可怜肝脏.
91Then it converts acetyl aldehyde into acetic acid.然后将乙酰甲醛转化为乙酸.
92Acetic acid, you might have heard me talk about it before.乙酸,你可能听说过我之前谈论它。
93It is a molecule that we find in vinegar.它是我们在醋中找到的分子。
94Now, this molecule is not a poison.这分子不是毒药
95This molecule is safe for the body.这个分子对身体是安全的.
96And you might think, oh, well, if my liver is turning ethanol into basically a vinegar compound,你可能会认为 如果我的肝脏把乙醇变成醋类化合物
97then not much is going to happen to me, right?那样我就不会出什么事了,对吧?
98This is incorrect.这不正确。
99You see, it all has to do with the breakdown speed.你看,这一切都与崩溃的速度有关。
100So your liver cannot instantly turn all the ethanol into your body, into acetic acid.所以,你的肝脏不能立刻把所有的乙醇转化为你的身体,变成乙酸.
101This process takes time.这一过程需要时间。
102I want to show you a specific study that I think is so interesting.我想给大家看一个特别的研究 我觉得很有趣
103So this study is called Cytokine Changes Following Acute Ethanol Intoxication in Healthy Men,因此,这个研究被称为Cytokine 改变 后急性乙醇中毒 在健康男性,
104a crossover study.一个交叉研究。
105So in this study, and obviously scientists do some amazing things,所以在这个研究中 科学家们显然做了一些令人惊奇的事情
106they gave young males 300 milliliters of pure vodka to drink on an empty stomach.他们给了年轻男性300毫升纯伏特加 在空胃上饮用。
107300 ml is about the size of a soda can.300毫升大约是一个汽水罐的大小.
108So imagine drinking all of this on an empty stomach of pure vodka in just 30 minutes.想象一下,在30分钟内 把这些都喝在纯伏特加的空胃上
109Yeah, pretty intense.是啊,相当激烈。
110And then the researchers tracked the elimination of ethanol in the body of these participants.然后研究人员跟踪了这些参与者体内乙醇的消除情况.
111And they found that it takes, on average, five hours for our body to get rid of just他们发现,我们的身体平均需要5小时才能摆脱
112half the amount of ethanol that was ingested.摄入的乙醇量的一半
113So as you can see here, after about five, I would say like five to six hours even,如你所见,大概五到六小时后...
114you see that the ethanol concentration in the body of these participants你看到这些参与者体内的乙醇浓度
115is now half what it was at the very beginning.现在已经是最初的一半了
116So it takes a long time for our body to get rid of the ethanol.因此我们的身体需要很长的时间去除乙醇.
117And as it's getting rid of the ethanol, it's being exposed to ethanol, but also to acetyl aldehyde.而随着乙醇的脱落,它也暴露在乙醇中,但也暴露在乙酰甲醛中.
118So let's go back to this graph with the pasta and the red wine.故以面和红酒回此图.
119So another thing you should know about the liver is that it's actually in charge肝脏的另外一点你应该知道 肝脏是负责的
120of regulating the amount of glucose in your body.控制体内的葡萄糖量
121Now, when you drink alcohol, as I just told you, your liver is super busy doing all of现在,当你喝酒, 正如我刚才告诉你, 你的肝是超级忙做所有
122these transformations to transform it into different compounds.这些转变将它转化为不同的化合物。
123And as a result, it doesn't have the time to manage your glucose levels like it usually does.因此,它没有时间像通常那样管理你的葡萄糖水平.
124And that is why you see this decrease in a glucose spike when you add alcohol to a meal.所以当您在一顿饭中加入酒精时,您会看到葡萄糖的含量下降。
125It's because your liver is busy with this poison that you've just given it,因为你的肝脏忙于这个毒药 你刚刚给了它,
126so it cannot manage your glucose levels as effectively.所以它不能有效地管理你的葡萄糖水平。
127As a result, you see a smaller spike, but it's because you're poisoning your liver.因此,你可以看到一个较小的螺旋, 但这是因为你正在中毒你的肝脏。
128So it is not a good idea, my dear friends, to add red wine to your pasta,因此,这不是一个好主意,亲爱的朋友们, 加入红酒 你的面条,
129even though this graph shows us something a bit confusing and something we could interpret as that.尽管这个图表向我们展示了一些令人困惑的东西, 以及我们可以这样解释的东西。
130But again, not a good idea.但还是不行
131If you want to manage your glucose levels, which is the foundation of physical and mental health.如果你想控制你的葡萄糖水平,这是身心健康的基础.
132So what goes on as this ethanol and acetyl aldehyde are in your body causing damage?那么,这乙醇和乙酰甲醛 在你的体内造成什么损害?
133Let's have a quick look organ by organ so you can see what's going on让我们快速的 器官外观 这样你就可以看到发生了什么
134inside of your body and your brain when you drink alcohol.当你喝酒的时候,你的身体和大脑。
135So the first place to look is your stomach and your intestine.故先观于胃与肠.
136As I mentioned, alcohol, ethanol goes right there.正如我所提到的,酒精,乙醇就在那里。
137And once it is in your stomach and your intestine,一旦在你的胃和肠子里
138unfortunately, ethanol damages the cells that line your gut.很不幸,乙醇会破坏你的肠道
139And this leads to a few things.这导致了一些事情。
140First of all, you can't absorb nutrients from your food as effectively as you're used to,首先,你不能像以前那样有效地吸收食物中的营养,
141which is why in people who drink a lot of alcohol, we see nutrient deficiencies often.这就是为什么在喝了很多酒的人中, 我们经常看到营养不足。
142Second, as it damages the cells, it can actually lead to leaky gut syndrome.第二,当它破坏细胞, 它实际上可以导致漏泄性肠道综合征。
143IBS, leaky gut, such a common condition today.IBS,泄密的肠胃, 这样的常见条件今天。
144And we know that alcohol makes it worse.我们知道酒精会让情况更糟
145And finally, if that wasn't enough, alcohol kills all of the good bacteria in your gut.最后,如果还不够的话, 酒精会杀死你体内所有好的细菌。
146And you might know this because we can often use alcohol to disinfect something.你可能知道这一点,因为我们常常可以使用酒精来消毒一些东西。
147And what does it mean to disinfect something?消毒有什么意义?
148It means to kill all the bacteria.谓杀灭一切细菌.
149So ethanol is rushing around your body and your bloodstream and it also gets to your brain.乙醇在你的体内和血液中冲动 也进入你的大脑
150Now, here what's really interesting is that we have this thing called the blood-brain barrier,现在,这里真正有趣的是, 我们有这个东西 叫做血脑屏障,
151which is supposed to protect the brain from pathogens.它可以保护大脑免受病原体的影响
152But actually, ethanol crosses that barrier.但实际上,乙醇会穿过这个屏障。
153The ethanol, the alcohol makes its way into your brain.乙醇,酒精 进入你的大脑。
154Yes, and here a few things happen.是的,在这里发生了一些事情。
155The first thing that happens is that ethanol makes your brain release dopamine.第一件事是乙醇让你的大脑释放多巴胺。
156And as you might have heard me talk about, dopamine is the pleasure molecule.正如你可能听到的, 多巴胺是快乐分子。
157It gets released when we have sex, when we play video games, when people do illegal drugs,当我们发生性关系, 当我们玩电子游戏, 当人们做非法毒品,
158and when you drink alcohol.当你喝酒的时候
159And the problem is, dopamine to your brain feels like a reward.问题是,多巴胺对你的大脑 是一种奖励。
160So your brain gets tricked into thinking that this poison actually makes it feel rewarded.所以,你的大脑被骗到 认为这个毒药实际上 使它感到回报。
161It makes it feel good and happy.令其心生欢喜.
162And now, some people get more dopamine than others when they drink.现在,有些人喝多巴胺比其他人多。
163And generally, you're able to recognize yourself.一般来说,你可以认出自己
164If when you have alcohol, you feel euphoric, you feel so happy, so excited, you feel so much better,如果你有酒,你感到兴奋,你感到 如此快乐,如此兴奋,你感觉好多了,
165that's probably because your brain releases more dopamine than other people's brains.这可能是因为你的大脑释放的多巴胺比其他人的大脑多。
166Isn't that so interesting?这不是很有趣吗?
167So we each have a different amount of dopamine that gets released in our brain when we drink alcohol.所以,我们每个人都有 不同的多巴胺量, 当我们喝酒时,我们大脑释放出来。
168And in fact, as you can imagine, people who are heavy drinkers generally have a higher事实上,你可以想象, 喝重酒的人 通常有一个更高的
169dopamine release when they drink alcohol.多巴胺在饮酒时释放出来.
170It feels like more of a reward.感觉更像是奖励
171They feel so good that they just want to keep coming back for more.他们感觉好极了 他们只想继续回来找更多
172The second molecule that gets activated in our brain when we drink alcohol is serotonin.我们喝酒后脑中的第二个分子是血清素。
173Serotonin is the happy hormone, right?血清素是快乐的荷尔蒙 对吧?
174So it's the one that makes you feel comfortable, relaxed, happy, at ease.所以它让你觉得舒服,放松,快乐,轻松。
175So you have dopamine being activated, which makes you feel pleasure and reward.所以多巴胺被激活了 让你感到快乐和回报
176And then serotonin, which is happiness, you know, chilled, feels so good molecule.然后血清素,这就是快乐,你知道, 冷却,感觉非常好的分子。
177So there's a lot of stuff in your brain that goes on.所以,很多东西 在你的大脑中,继续。
178And that's why people drink alcohol is because it releases these two molecules这就是为什么人们喝酒 因为它释放了这两个分子
179that make us feel good.这让我们感觉很好。
180But then this does not last forever.但是,这种情况不会永远持续下去。
181Once these get released and activated, then comes the shutdown.一旦这些被释放并激活, 就会有关闭。
182So other processes take over.因此,其他进程接管。
183And instead of just feeling really good, I'm really happy.而不是只是感觉真的很好, 我真的很开心。
184You're going to start to feel some of the toxic damage你会开始感受到一些毒害
185that ethanol and acetaldehyde are doing to your neurons.乙醇和乙醛对神经元有影响
186So let's talk about your neurons.我们来谈谈你的神经元
187Ethanol and acetaldehyde are going to heavily damage your brain cells called neurons.乙醇和乙醛会严重损坏你的脑细胞 叫做神经元
188And specifically, they actually touch and hurt your neurons that are in charge具体来说,他们实际上触摸并伤害了负责的神经元
189of managing your impulses, of helping you be aware of your surroundings,控制你的冲动 帮助你了解周围环境
190the ones that manage good judgment, motor coordination.那些能做出正确判断的人 机动协调
191And they also suppress the neurons that are able to form memories,它们也会抑制能够形成记忆的神经元,
192which is why you remember fewer things when you drink alcohol.这就是为什么你记得少的东西 当你喝酒。
193So these two toxins literally suppress and turn off所以这两种毒素 完全抑制和关闭
194and damage a lot of neurons in your brain.并破坏很多神经元 在你的大脑。
195And so when you feel drunk, that's actually the feeling of your neurons所以当你觉得喝醉了, 这其实是你的神经元的感觉
196being damaged and suppressed.被破坏和压制。
197Another quite detrimental effect of drinking alcohol is that酗酒的另一个相当有害的后果是
198when you're a habitual alcohol user, the days when you don't drink经常喝酒的时候,不喝酒的日子
199and the moments when you're not drinking, you end up feeling worse和不喝酒的瞬间, 你最后感觉更糟
200during those days and those moments.在那些日子和那些时刻
201And you end up needing alcohol to feel good again.你最终需要酒精来再次感觉好。
202So it's almost as if your baseline of happiness and enjoyment reduces所以,它几乎就像你的基线 幸福和享受减少
203and you become more and more dependent on alcohol to make you feel good.你越来越依赖酒精 让你感觉很好
204You develop a dependence.你发展了一种依赖。
205There's a study that I want to mention that I think is so interesting.有个研究我想说 我觉得很有趣
206It's called Effect of Alcohol on the Central Nervous System这叫酒精对神经系统的影响
207to Develop Neurological Disorder.用于发展神经病。
208And so this paper is super interesting.这篇论文非常有趣。
209It goes into detail about the exact effects of alcohol on our neurons.它详细介绍了酒精对我们神经元的确切影响.
210And it explains that alcohol creates DNA damage in our neurons.它解释了酒精给我们的神经元造成了DNA损伤。
211And the errors accumulate over time and lead to dysfunction.而错误会随着时间累积,导致功能失调.
212So it's not like you drink, your neurons shut down,所以,这不像你喝酒, 你的神经元关闭,
213and then you stop drinking for a few hours and your neurons come back up.然后,你停止喝酒 几个小时, 你的神经元回来。
214There is damage that accumulates over time in the DNA of your brain cells.脑细胞的DNA会积聚一些损伤
215Alcohol also accelerates the aging of our neurons and of our brains.酒精还加速了神经元和大脑的衰老。
216So our brain ends up aging faster the more and the more we drink.所以我们的大脑会越来越老化 我们喝得越多
217And not only does alcohol kill existing neurons,不仅酒精会杀死现有的神经元
218it also prevents new ones from forming.它也阻止了新的生物形成。
219And this can lead to all sorts of effects on processing,这会导致各种影响 处理,
220cognitive ability, memories, spatial awareness.认知能力,记忆,空间意识.
221For example, when somebody has a stroke,比如,当某人中风时,
222well, parts of their brain, some of their neurons die, right?脑部的部位 神经元会死亡 对吧?
223And this can cause extreme symptoms and consequences.这会造成极端症状和后果。
224But with alcohol, it's like you're having a very, very slow,但是,用酒精, 它就像你有一个非常,非常慢,
225very, very, very gradual stroke.非常非常,非常,非常渐进的中风。
226And we've known for a very long time in all of the studies我们在所有的研究中都认识很久了
227that three drinks a day is clearly damaging to the brain.每天喝三杯显然会伤害大脑
228So if you have three drinks a day every single day,所以如果你每天喝三杯的话
229that's a very slow damage, slow stroke, if you will.这是一个非常缓慢的损伤, 缓慢中风,如果你愿意。
230It's not a perfect comparison.这不是一个完美的比较。
231But in terms of the effect on neurons,但从对神经元的影响来看,
232very slow damage to your brain.脑部损伤很慢
233And we've known again for a very long time我们又认识很久了
234that three drinks a day is really bad.一天喝三杯真的很烂
235But you might have heard,但你可能听说了
236and this is something that I heard when I was younger and growing up,这是我年轻和长大时听到的
237that actually one drink a day is good for you.其实一天喝一杯对你有好处
238And this was believed for a very long time.这被人们相信了很长一段时间。
239And I'm French.我是法国人
240And let me tell you, most French people still believe that.让我告诉你,大多数法国人仍然相信这一点。
241And it's not their fault.这不是他们的错。
242It's because they just don't know the latest science.因为他们不知道最新的科学
243And a lot of doctors don't even know the latest science either.很多医生甚至不知道最新的科学
244So let's talk about that.所以,让我们谈谈。
245Is one or two drinks a day good for you or not?你一天喝一两杯好吗?
246This belief was based on associative studies这种信念是基于联合研究
247that showed that if you look at a big population,这说明如果你看一大群人
248a big group of people,一大群人,
249people who have one drink a day一天喝一杯的人吗?
250seemed to be healthier than people who had zero drinks a day.似乎比每天不喝酒的人更健康
251And recently scientists have started to see最近科学家们开始看到
252the main massive holes in this kind of research,这种研究的主要大洞,
253notably two important things.特别是两件事
254Number one, the main flaw in these studies第一,这些研究的主要缺陷
255is that previous heavy drinkers是那个喝重酒的
256who stopped drinking entirely for health reasons完全出于健康原因停止喝酒
257were now in the zero drinks a day category.已经是零饮料了
258But they were actually quite unhealthy但他们其实很不健康
259because they probably were drinking before,因为他们可能以前喝酒,
260but they completely stopped because of cancer,但他们完全停止 因为癌症,
261heart disease, diabetes, you name it.心脏病,糖尿病,你说的
262So now you had all these unhealthy people现在你有这么多不健康的人
263in the zero drinks a day category.在零饮料一天类别。
264Interesting, right?有意思,对吧?
265And you also saw a lot of old people你也见过很多老人
266who had one drink a day and who were healthy.他们一天喝一杯,他们很健康。
267And they probably kept drinking one drink a day他们可能一天喝一次
268because they didn't have any health issues.因为他们没有任何健康问题。
269It's not that the one drink a day不是那个一天喝酒的人
270was keeping them healthy in later age.让他们在晚年保持健康
271It's just simply that because they didn't develop chronic issues仅仅是因为他们没有产生长期的问题
272and their doctor didn't say,他们的医生没说
273you got to cut out all the wine and the vodka,你要切掉所有的酒和伏特加,
274one drink a day was not causing their good health.一天喝一杯不会让他们身体健康
275The one drink a day was a consequence of their good health.一天喝酒是他们身体健康的结果。
276So these associative studies now have been shown因此,这些关联研究 现在已经显示
277{\fn黑体\fs22\bord1\shad0\3aHBE\4aH00\fscx67\fscy66\2cHFFFFFF\3cH808080}只是严重缺陷
278So we don't really rely on them anymore.所以我们不再真正依赖他们了。
279But what we do look at, which is incredibly interesting,但我们所看到的, 这令人难以置信的有趣,
280are two new studies that came out in 2022,2022年出版的两部新书
281which really helped us understand what's going on这真的帮助我们 了解发生了什么
282even in the light drinking category.即使是轻度饮酒
283So the first study is called所以第一个研究叫做
284Associations Between Alcohol Consumption酒精消费协会
285and Grey and White Matter Volumes in the UK Biobank.和灰白物质卷 在英国生物银行。
286And this is from data on 40,000 people.这是来自4万人的数据。
287And this study showed very clearly that just one drink a day这份研究非常清楚地表明 每天只喝一次
288was associated with our brain shrinking,和我们的大脑萎缩有关
289death of neurons, cognitive decline, thinning of the brain.神经元死亡 认知下降 大脑变薄
290So this study showed us that even just one drink a day所以这个研究告诉我们,即使一天只喝一杯
291is accelerating our brain aging.正在加速我们的大脑老化。
292Now, of course, aging and shrinking of the brain现在,当然,老化 和缩小的大脑
293as you age is normal.像你这个年纪一样正常
294This is not something that we can completely get rid of.这不是我们可以完全摆脱的
295But you have to understand that by just having one drink a day,但你必须明白 只要一天喝一杯
296you are accelerating this shrinking你正在加速收缩
297and this aging of your brain.你的大脑老化了
298Just one drink a day, which so many people are doing.每天只喝一杯 很多人都在喝
299So I'm not saying you should stop drinking.我不是说你应该停止喝酒
300I'm just saying you need to weigh the pros and cons.我只是说你需要权衡利弊
301And we're not totally done yet我们还没完呢
302because there's more stuff you need to know.因为你需要知道更多事情
303The second study to know about is called第二项研究叫做
304Association of Habitual Alcohol Intake有机酒精摄入量协会
305with Risk of Cardiovascular Disease.有心血管疾病的风险
306And so in this research,所以在这项研究中,
307they looked again at those big associative studies他们又重新审视了这些大联合研究
308on alcohol and heart disease酒精和心脏病
309because again, previously people thought因为以前人们也认为
310one drink a day was good for their heart.一天喝一杯对心脏有好处
311And they showed that when you remove the confounding variables他们显示,当你去掉困惑的变量
312that I'm talking about,我说的,
313all the previously believed benefits of alcohol所有以前相信 酒精的好处
314completely disappear.彻底消失。
315So now we know that this thing of one drink a day所以,现在我们知道, 这东西一天一喝
316is good for you is not true.对你有好处 不是真的
317Alcohol, even at a very low quantity of one drink a day喝酒,即使每天喝一杯也很少
318is damaging your brain.正在破坏你的大脑。
319And if you look at the brain of an old person,如果你看着老人的大脑
320let's say if you know somebody who's in their 80s or 90s,如果你认识80或90岁的人
321you can tell their brain is not as sharp你可以看到他们的大脑没有那么锋利
322as somebody who's say in their 20s or 30s or 40s, right?像是20或30或40岁的人 对吧?
323That is aging of the brain.这是脑衰老。
324And the more you drink, the faster you are going to be你喝得越多,你就会越快
325in a state where your brain is unhealthy and old and damaged.在你的大脑不健康 年老和受损的状态下
326Sorry, guys.对不起,伙计们。
327Just got to know the truth.璶笵痷
328Oh, and a side note on Alzheimer's.哦 还有阿尔茨海默症的副笔记
329If you're predisposed to dedicate to Alzheimer's,如果你愿意献给老年痴呆症
330drinking heavily increases your risk of actually developing it.酗酒会增加你真正开发它的风险
331Again, it's bad for the brain.复次恶智.
332So if your brain is sensitive,所以如果你的大脑敏感,
333if your brain has any predispositions,如果你的大脑有任何倾向,
334if there's cognitive decline in Alzheimer's in your family,如果你家的阿尔茨海默症 认知下降
335for example, it's a good idea to lay off on the alcohol举例来说,一个好主意是解雇酒
336so that you can prevent your brain from aging这样你就可以防止你的大脑老化
337and damaging too quickly.并且破坏太快。
338So another way that alcohol impacts us is on our sleep.酒精影响我们的另一个方式就是在睡觉。
339I'm sure you've made this experience.我敢肯定,你创造了这个经验。
340When you drink, you don't sleep as well.饮时不眠.
341You wake up in the night.你晚上醒来。
342You don't feel super good in the morning你早上感觉不太好
343because you haven't slept very well because of all of the alcohol.因为你一直睡不好 因为所有的酒精。
344So specifically, when we drink alcohol,所以,特别的, 当我们喝酒,
345we have less restful and less deep sleep.我们的休息和睡眠都比较少
346And our brain can't do something that it generally does during our sleep,我们的大脑不能做 通常它在我们睡眠中做的事情,
347which is to clean up all the toxins from the day.也就是从今天开始清除所有的毒素
348So when there's ethanol and acetal aldehyde in there,所以,当有乙醇和乙酰乙醛在那里,
349it doesn't clean things up,它不会清理东西,
350which is one of the reasons we feel so bad in the morning.这也是我们早上感觉很糟的原因之一
351Okay, some more negative impacts.好吧,一些更多的负面影响。
352I promise we're almost done with the negatives now.我保证我们快搞定底片了
353DNA damage in the cells increases the risk of cancer,细胞中的DNA损伤增加了癌症的风险,
354inflammation, huge increase in inflammation in your body炎症,你体内炎症急剧增加
355when you drink alcohol.当你喝酒。
356And today, two out of three people are going to die今天,三个人中有两个人要死了
357of an inflammation-based disease.一种炎症引起的疾病。
358Cancer, diabetes, heart disease, et cetera,癌症、糖尿病、心脏病等
359are all inflammation-based diseases.这些都是炎症引起的疾病。
360Alcohol increases inflammation酒精增加炎症
361and it makes your immune function worse.它让你的免疫功能更差。
362So if you have things like psoriasis, eczema, arthritis,所以,如果你有 诸如 p,风疹,关节炎,
363autoimmune diseases, alcohol does not help you.自动免疫疾病,酒精对你有帮助。
364It makes it worse.令其更恶.
365And finally, cancer.最后还有癌症
366So alcohol is defined as a group one carcinogen所以酒精被定义为第一组致癌物质
367by the International Agency for Research on Cancer.国际癌症研究机构。
368And group one is, as they say, the highest risk group正如他们说的,第一组是最危险的组
369and includes other known carcinogens包括其他已知致癌物
370like asbestos, radiation, and tobacco.比如石棉、辐射和烟草
371The connection between alcohol and cancer is so incredibly clear.酒精和癌症之间的联系非常明确。
372And the more alcohol you drink,你喝的酒越多,
373the more likely you are to get many, many different cancers,你愈有可能患上多种不同的癌症
374notably because alcohol causes DNA mutations.特别是酒精会导致DNA突变
375And the link between breast cancer is even stronger乳腺癌之间的联系更加紧密
376than for all other cancers.比其他癌症都严重
377So in a study called Alcohol Use and Breast Cancer,在一项名为酒精使用和乳腺癌的研究中
378a critical review, the results were very clear.一项批判性审查的结果非常清楚。
379Any amount of alcohol, even very light drinkers,任何酒精量,即使是非常轻的饮酒者,
380one drink a day increases the likelihood of breast cancer.每天喝一次会增加患乳腺癌的可能性。
381And the more you drink, the higher the risk.你喝得越多 风险就越大
382So if you want to avoid cancer,如果你想避免癌症的发生
383avoiding alcohol is very important.避免酗酒是非常重要的。
384And final thing I wanted to mention, fertility and hormones.最后我想说的是生育力和激素。
385Females who drink have higher experience of PMS syndrome女性饮酒者患PMS综合症的经验较高
386or less fertile, have higher levels of testosterone或肥沃程度较低的睾酮含量较高
387and hormonal imbalances in the body.和体内的激素不平衡。
388Same story for men.男人也一样
389Alcohol use impacts sperm quality and your hormones.酒精会影响精子质量和你的荷尔蒙
390So the picture is not so great, I have to say.所以我不得不说,这张照片不是那么棒。
391Looking at all this, I was like, wow,看着这一切,我就像,哇,
392people don't know much about all the side effects of alcohol.人们不太了解酒精的所有副作用。
393So I hope you've learned a bit.所以我希望你学到一点
394And now we're going to talk about hangovers.现在我们要谈谈宿醉
395So kind of strangely, hangovers are not very well understood奇怪的是, 宿醉的人不太了解
396by scientists.科学家们
397There's a few different theories.有几种不同理论.
398So, you know, they say something like alcohol causes dehydration,所以,你知道,他们说的东西 像酒精会导致脱水,
399inflammation on the brain of body, alterations in your hormones.身体脑部的炎症 激素的改变
400It dilates your blood vessels and then your vessels它会扩大你的血管,然后你的血管
401recontract when ethanol leaves your body.当乙醇离开你的身体时 重新签约
402So that could cause migraines.这样可能会引起偏头痛.
403But basically, hangovers are still kind of mystery,但基本上 宿醉仍然是个谜
404but we all know what happens after we drink.但我们都知道酒后会怎样
405We get hangovers.我们得到宿醉。
406I mean, some people more or less than others,我的意思是,有些人或多或少 比其他人,
407but hangovers are the main consequence.但宿醉是主要后果。
408And I want to talk about something that is so interesting我想谈谈有趣的事
409about hangovers.关于宿醉。
410So ideally, we would want to help our body process最好能帮助我们的身体
411the ethanol faster so that the toxic ethanol更快的乙醇 这样有毒的乙醇
412and acetaldehyde hang around for less long in our body,乙醛在我们身体里停留的时间更少
413causing less damage, right?伤害较小,对不对?
414So one important thing that you should definitely never have所以有件事你绝对不应该有
415after you drink alcohol is to have Tylenol, acetaminophen喝完酒后,就喝Tylenol 乙酰胺酚
416or any other products like that because they slow down或其他产品,因为慢下来
417the metabolism of ethanol in the liver.肝脏中乙醇的代谢.
418So those toxins are going to stay for longer in your body所以那些毒素会留在你体内更长的时间
419and cause even more damage.并造成更大的损害。
420Another really crazy thing that I learned in the science我从科学中学到的另一件很疯狂的事
421is that fructose, which is a sugar that's found in fruits,是果糖,是水果中的糖,
422but also in sort of processed sodas,也是一种经过加工的汽水,
423high fructose corn syrup actually helps your body,高果糖玉米糖浆能帮助你的身体
424your liver process ethanol faster.你的肝脏能更快地处理乙醇
425That's not to say you should add sugar to your drinks不是说你应该在饮料里加糖
426because when you add sugar, you're also creating因为当你加糖的时候,你也在创造
427different side effects from the sugar.糖的不同副作用。
428But if there was a way to have sugar without having sugar,但如果有办法不吃糖就吃糖
429it would help our liver process the ethanol faster.它会帮助我们的肝脏 更快地处理乙醇。
430But that's a sidebar.但那是边栏
431Don't add sugar to your alcoholic drinks.不要在酒精饮料里加糖
432It's just an interesting little fact from the scientific studies.这仅仅是科学研究中一个有趣的小事实.
433So if you have, for example, wine versus having a cocktail,所以,如果你有,例如, 酒与有鸡尾酒,
434like you see on this graph,就像你看到的这个图表,
435so the wine is going to cause less of a glucose spike葡萄酒会减少葡萄糖的含量
436because it contains less sugar.因为它含有较少的糖。
437The cocktail that contains sugar will cause a glucose spike含糖的鸡尾酒会引起葡萄糖尖刺
438and will cause liver damage.并会造成肝脏损伤。
439So in fact, if you want to pick the alcohol所以事实上 如果你想挑酒
440that is going to be least bad for your body,这会对你的身体造成最小的伤害,
441go for an alcohol that is not mixed with sugar.去喝不与糖混合的酒精
442So go for wine or beer or spirits with soda water所以去喝酒 喝啤酒 喝水
443instead of a heavy sugar cocktail而不是重糖鸡尾酒
444so that you don't give your liver two things这样你就不会给你的肝脏两件事
445to handle, the ethanol and the sugar, because that's a lot.处理, 乙醇和糖, 因为这是很多。
446So my dears, tips if you drink alcohol.所以,亲爱的,小费 如果你喝酒。
447This is my summary of the most recent research.这是我最近研究的总结。
448Number one, pace yourself.第一,快一点
449Drink slowly so that you don't give your liver慢慢喝,这样你就不会给肝脏
450so much ethanol to process all at once这么多乙醇可以同时加工
451so that the ethanol and the toxic byproducts使乙醇和有毒副产品
452don't stay in your body for too long.别在身体里呆太久了
453Okay, so drink slowly.好,慢慢来
454One drink an hour is much better than having 10 shots in 10 minutes.一小时喝一杯比十分钟内喝十杯好
455Okay, so pace yourself.好吧,你快点
456Second, eat food before you drink.第二,先吃饭再喝酒.
457Why?为什么?
458Because that's going to slow down the speed因为那样会减慢速度
459at which the ethanol will arrive into your liver.乙醇会进入你的肝脏
460Again, giving your liver a break and helping it process things再说一次,让你的肝脏断裂,帮助它处理事情
461at a pace that it can actually handle.以它实际能承受的速度
462Another really good tip.另一个非常好的提示。
463Tip number three, exercising.提示三,锻炼。
464So there's a 2017 study that showed us2017年的研究显示
465that the most protective thing we can do那是我们所能做的最保护的事
466to help our body counteract the bad side effects of ethanol帮助身体抵御乙醇的不良副作用
467is exercising.正在锻炼。
468This study even shows that exercise can attenuate,这项研究甚至表明,锻炼可能会减弱,
469reduce the side effects of alcohol on cancer.减少酒精对癌症的副作用。
470So exercise several times a week as much as you can.每周尽可能锻炼几次
471It's also the best thing you can do这也是你能做的最好的事
472for your health overall and longevity.为了你的健康 和长寿。
473But if you drink and you want to reduce some of the side effects,但如果你喝了酒 想减少一些副作用
474exercise is the absolute best thing to do.锻炼是绝对最好的选择。
475Tip number four, drink far from sleep time.第四小节 喝得离睡觉时间很远
476Because again, we talked about ethanol having an impact on your brain再说一遍,乙醇会影响你的大脑
477and then if you're having something sweet with a cocktail,然后如果你有 甜的东西与鸡尾酒,
478that sugar is also going to impact your deep sleep糖也会影响你深睡
479and your restfulness when you wake up in the morning.以及早晨醒来时的静静。
480Number five, eat fermented foods like kimchi5号,吃发酵的食物,像金鸡一样
481to replenish all your gut bacteria that was destroyed by the ethanol.补充你被乙醇摧毁的肠道细菌
482So add that to your routine, add that to your day.所以,加上你的常规, 加上你的一天。
483It's going to help your gut heal.这会帮助你的肠道愈合。
484And finally, if you've been drinking, my dears, in the morning,最后,如果你一直在喝酒, 亲爱的,早上,
485I know it's tempting to go for something carby and sugary我知道去吃卡比和甜点很诱人
486because you just don't feel very well because you're hungover.因为你因为宿醉而不舒服
487But the best thing you can do is to have a savory breakfast但最好的办法就是吃个美味的早餐
488with lots of protein, something that's not going to create a glucose spike,和很多蛋白质, 的东西不会产生葡萄糖尖刺,
489something that's not going to give your body even more stuff to deal with.让你的身体更难处理
490So that the next morning when you're hungover,所以第二天早上当你宿醉时
491you have a breakfast that's really good for you你有一个早餐 真的很适合你
492and that's going to help your body thrive.这会帮助你的身体繁荣。
493So that was the episode on alcohol.这就是关于酒的一集。
494To be honest, as I was looking at all of this research,老实说,当我看着所有这些研究时,
495I was quite surprised.我很惊讶。
496I didn't understand.我没听懂
497I knew alcohol was bad for us.我知道酒精对我们不利
498I think I didn't understand the extent to which it affected我想我不明白 影响的程度
499so many parts of our body and our brain.我们身体和大脑的很多部分
500And I kind of wonder when we have this kind of data on the damage it does,我有点奇怪 当我们有这种数据 有关它的伤害,
501why it's not treated today like cigarettes are treated, for example.比如说,为什么今天没有像香烟一样对待它。
502Why have we increased the cost of cigarettes为什么我们增加香烟的费用?
503and put all these warnings on them to help people reduce their consumption?然后用这些警告来帮助人们减少消费?
504But we haven't really done that with alcohol.但我们还没有真正做 与酒精。
505I don't know.师曰.
506So I hope that this was interesting我希望这很有趣
507and I hope you'll draw whatever conclusions you want to draw from this.我希望你能从中得出任何结论
508But at least you have the data.但至少你有数据。
509Alcohol is a toxin.酒精是一种毒素。
510It's bad for you.尔时阿难.
511It does increase dopamine and serotonin in your brain,它的确增加了多巴胺和血清素 在你的大脑,
512which is why it makes you feel good.这就是为什么它让你感觉很好。
513And the rest is up to you.其余的由你决定
514Lots of love.很多爱。
515I'll see you next time.下次见
该视频共有字幕 515 条。解锁更多字幕为会员功能,请移动到 价格