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耶鲁公卫学院前院长关心的健康威胁:“永久性化学品”PFAS与

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时间英文中文
0:06Good evening everybody, welcome.大家晚上好 欢迎光临
0:09Thank you so much for coming here非常感谢你来到这里
0:12to the Yale Center of Beijing.到北京耶鲁中心.
0:14My name is Lina and I am a graduate of Yale University我叫莉娜 我是耶鲁大学毕业生
0:18and the Yale School of Public Health.和耶鲁大学公共卫生学院。
0:20So this program is very near and dear to my heart所以这个节目对我来说非常亲切
0:23because our guest today is Stan Vermind,因为我们今天的客人是斯坦·弗明
0:27who is the former Dean of the Yale School of Public Health前任耶鲁大学公共卫生学院院长
0:30and who's going to teach us a lot谁会教我们很多
0:32about a very, very important topic today.是关于今天一个非常重要的话题
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序号英文中文
1Good evening everybody, welcome.大家晚上好 欢迎光临
2Thank you so much for coming here非常感谢你来到这里
3to the Yale Center of Beijing.到北京耶鲁中心.
4My name is Lina and I am a graduate of Yale University我叫莉娜 我是耶鲁大学毕业生
5and the Yale School of Public Health.和耶鲁大学公共卫生学院。
6So this program is very near and dear to my heart所以这个节目对我来说非常亲切
7because our guest today is Stan Vermind,因为我们今天的客人是斯坦·弗明
8who is the former Dean of the Yale School of Public Health前任耶鲁大学公共卫生学院院长
9and who's going to teach us a lot谁会教我们很多
10about a very, very important topic today.是关于今天一个非常重要的话题
11So a little bit about our center here.一点点关于我们的中心。
12Basically the center is Yale University's home in China基本上中心是耶鲁大学在中国的家
13and we have been here for almost 10 years, since 2014.自2014年以来,我们在这里已近十年。
14And this is Yale's only university-wide center这是耶鲁唯一的大学中心
15representing all 15 schools of Yale.代表耶鲁的所有15所学校。
16So it's the only center outside of the US所以这是美国以外唯一的中心
17and we happen to be in the wonderful Beijing.我们恰巧在美妙的北京
18So today, as you know, we're gonna talk about PFAS所以,今天,你知道, 我们要谈论PFAS
19and microplastic or forever chemicals.和微塑料或永远的化学品。
20Professor Vermind is actually a wonderful researcher,弗明德教授其实是个出色的研究员
21pediatrician, epidemiologist, and a global health star儿科医生、流行病学家和全球卫生明星
22who has projects all over the world,他在世界各地有项目,
23especially focused on low and middle income countries特别侧重于中低收入国家
24and in places like Zambia and Mozambique, Nigeria, China,赞比亚和莫桑比克、尼日利亚、中国,
25on topics ranging from HIV to COVID.关于从艾滋病毒到COVID的题目。
26So today we are going to talk about PFAS as you have read所以今天我们来谈谈你读过的PFAS
27and this is a very important topic for everyone,这对每个人都很重要
28mainly because we use these objects, these chemicals主要是因为我们使用这些物品,这些化学品
29in our everyday lives and now we know在日常生活中,现在我们知道
30that they also cause a lot of issues and health concerns,也引起了许多问题和健康问题,
31especially in young children.特别是在幼儿时期。
32So I'm very excited and I hope this is going所以,我很兴奋,我希望这是去
33to be a wonderful discussion.成为一场精彩的讨论。
34This event is actually co-hosted这个活动其实是联合主办的
35with the Yale Health Care Club of China中国耶鲁保健俱乐部
36and the Yale Club of Beijing和北京耶鲁俱乐部
37and to introduce the Yale Health Care Club of China并介绍中国耶鲁保健俱乐部
38is Selena Zhang, so I'll let her say a few words是张雪莲,我让她说几句话
39and then we'll go on to the discussion.然后我们继续讨论
40Thank you.谢谢
41Thanks the Yale Center of Beijing for this opportunity感谢北京耶鲁中心给我这个机会
42to give us the chance to co-host the event.给我们机会共同主办这个活动
43We are very honored to be here and actually we,我们非常荣幸来到这里,实际上我们,
44since the establishment of our club,自从我们俱乐部成立以来
45we have been a long-term friend with Yale Center of Beijing我们是北京耶鲁中心的长期朋友
46and also today it's our honor to have Stan here.今天我们很荣幸让斯坦来
47We have also established long-term relationship我们还建立了长期的关系
48with Yale Public School of Health与耶鲁公立卫生学校合作
49and especially under the guidance and the support特别是在指导和支持下
50with Dr. Stan Vermont, we have grown very fast in China和斯坦·佛蒙特医生一起,我们在中国发展很快
51and we have done so many events together.我们一起做了这么多事
52So yeah, we are very happy to be here today所以,是的,我们今天很高兴在这里
53and we will leave the precious time to Stan.我们会把宝贵的时间留给斯坦
54Thank you, Lena.谢谢你,莉娜。
55Thank you, Selena.谢谢你,塞琳娜
56It's a pleasure to be back at Yale Center of Beijing很高兴回到北京耶鲁中心
57and in China.和在中国。
58This is my third trip to China this year in 2023这是我今年在2023年第三次去中国旅行
59and it's a great pleasure each and every one of them.和它是一个伟大的快乐 每个人。
60I'm recovering from a bit of a cold and sore throat喉咙有点冷痛,我正在恢复
61和COVID负数倍,
62but if I don't sound quite myself, that's why.但是如果我听起来不太像自己,这就是原因。
63So let's go ahead and sort of objectives所以,让我们继续前进 排序的目标
64of this presentation.本介绍。
65I'd like to tell you about Forever Chemicals,我想告诉你关于永远的化学,
66give some plausible mechanisms for human health impacts,为人类健康带来一些可能的影响,
67review PFAS, but I also thought other micro-constituents检查PFAS, 但我也认为其他的微观结构
68would be of interest to you.你会感兴趣的。
69They're not strictly speaking Forever Chemicals,严格地说,他们不是永远的化学品,
70but they have long-term half-lives in nature但他们有 长期半衰期的性质
71and they're kind of related, you might say.可以说他们有某种亲缘关系
72And a little bit of, I couldn't be a pediatrician还有一点,我不能当儿科医生
73without mentioning the kids.不提孩子们。
74So we're all familiar with macro-constituents.所以我们都熟悉宏观结构.
75These are natural and man-made substances这些是天然的和人造的物质
76in the environment that we can see我们可以看到的环境
77and visible products of the earth, buildings,以及大地和建筑物的明显产物,
78vehicles, equipment, but also waste, plastics, pollution,车辆、设备、废物、塑料、污染
79things that we can see.我们可以看到的东西。
80So macro-constituents can be beautiful所以宏观结构是美丽的
81like the Petronas Towers of Kuala Lumpur,就像吉隆坡的彼得罗纳斯塔
82or useful like this sea of bicycles或者像这群自行车一样有用
83that I saw in Chong Ping when I was there this summer,我今年夏天在崇平看到
84but it can also be ugly,但它也可能是丑陋的,
85like the great Pacific garbage patch.像伟大的太平洋垃圾场
86They say patch singular, but it's actually two of them,他们说是补丁单数 但其实是其中两个
87two areas of garbage, mostly plastics,两个垃圾区,主要是塑料
88that are floating over vast areas of the Pacific Ocean.漂浮在太平洋广大地区
89Here, oops, I didn't mean to do that.在这里,oops,我不是故意的。
90Here, the Western garbage patch off of Japan这里,日本的西方垃圾
91and the Eastern garbage patch和东部垃圾补丁
92between sort of off of Baja, California.在加利福尼亚州的巴哈之间
93And you have no idea how big these patches are.你不知道这些补丁有多大。
94If you combine them, they're about this,如果你把它们结合起来,他们就是这个样子,
95they're almost as big as the United States.它们几乎与美国一样大。
96So because of the eddies of the fluid, of the waters,所以由于流体,水的干燥,
97what happened, oh, there it is,发生了什么事,哦,这是,
98because they're sort of just circling, circling, circling,因为他们只是盘旋,盘旋,盘旋,
99and we add to them every day我们每天都在增加他们,
100with our pollution that goes into the ocean.我们的污染 进入海洋。
101So these are the macro-constituents,这些是宏观结构
102things we can see, things we know are there,我们能看到的东西, 我们知道的东西在那里,
103but micro-constituents, these are things like drugs.但微观结构,这些是药物。
104Drugs we take as humans, drugs that we give to our animals.我们把毒品当作人类 给动物的毒品
105Only a fraction of drugs are metabolized by our bodies.只有一小部分药物被我们的身体代谢。
106The rest gets excreted in our urine, sometimes our feces,其他人在尿液中排出粪便, 有时我们的粪便,
107and a lot of drugs are thrown away, discarded.和很多药物 扔掉,丢弃。
108Then we have food supplements.然后我们有食物补充。
109Some people call them nutraceuticals,有人称他们为神经病,
110nutrition supplements like vitamins and others,营养补充剂,如维生素等,
111the things you buy at the health food store,在健康食品店买的东西,
112and caffeine, nicotine, fragrances,和咖啡因,尼古丁,香料,
113pet products and supplements,宠物产品和补充品,
114all of these can end up in the environment.所有这些都可能最终发生在环境中.
115Things we use on our bodies like sunscreen agents我们用在身体上的东西 像防晒霜剂
116or lotions, shampoos, soaps, deodorants,或乳液、香精、肥皂、除臭剂,
117toothpaste, cosmetics.牙膏 化妆品
118We don't swallow our toothpaste,我们不吃牙膏
119we use it and then we spit it out, right?我们用它 然后我们吐出来,对不对?
120So when it's spit it out, it gets in the water supply.所以当吐出后,就会进入供水中.
121A fire retardants, I'll be telling you about those一个阻燃剂,我会告诉你这些
122in a little while, polybrominated diphenyl ethers.不久,多溴联苯醚。
123Sometimes they're called penta octane deca,有时它们被称为五辛烷十烷
124and they're PBDEs, try to say that five times fast.他们是多溴联苯醚,尝试说5倍快。
125PBDEs, PBDEs, I can't do it.多溴二苯醚,多溴二苯醚,我不能做到这一点。
126And organophosphate substitutions for these.和有机磷酸酯替代这些。
127And pesticides, which are bactericides, herbicides,还有杀虫剂,是杀菌剂,除草剂,
128fungicides, insecticides, all sorts of chemicals杀菌剂、杀虫剂、各种化学品
129that we put on our plants to protect them from bacteria,保护植物免受细菌感染,
130fun, plant killing, you know, killing,好玩,植物杀人,你知道,杀人
131killing weeds, fungi and insects.杀死杂草、真菌和昆虫
132And then there are of course the industrial chemicals当然还有工业化工
133and industry requires a lot of chemicals工业需要大量化学品
134to make the products that we use.制作我们使用的产品。
135And some of the chemicals are integrated有些化学物质已经融为一体
136into the product itself, and that ends up进入产品本身,最后
137in the environment when you discard the product.在环境中,当你丢弃产品。
138Others of them are side products of the manufacturing,其他的都是制造业的副产品,
139and they get discarded into the environment他们被丢弃到环境中
140more or less right away.或多或少马上
141And some of them accidentally get in.他们中有些人不小心进来了
142For example, you've got a lubricant on machinery.例如,你有一个润滑剂在机械上。
143But as the machinery is running,但是随着机器的运行
144the lubricant ends up in the environment,润滑剂会进入环境
145either aerosolized or it ends up being washed要么被喷雾,要么被冲洗
146when they wash the machinery, or it leaches out当他们洗机器,或它漏掉
147and it's cleaned up by the cleaning crew,被清洁人员清理干净了
148but it ends up in the environment.但它最终会进入环境。
149And some of these industrial chemicals还有一些工业化学品
150are these forever chemicals that we're talking about.这些永远的化学物质,我们谈论。
151And we have bisphenol A, BPA, phthalates,我们有双酚A,BPA,邻苯二甲酸酯,
152and these relatives of PFAS, PFOS and PFA.以及全氟辛烷磺酰氟、全氟辛烷磺酸和全氟辛烷磺酰氟的这些亲缘关系。
153So these are all things in common use.这些都是常用的东西。
154Now, this is the emphasis of today's discourse,这就是今天讨论的重点
155which is the forever chemicals, the PFAS.这是永远的化学物质,PFAS。
156And just to tell you what a PFAS is,告诉你PFAS是什么
157there's how many carbons here?这里有多少碳?
158Two, four, six, eight.二四六八门.
159Eight carbons.八碳s.
160And this eight carbon backbone,这八个碳骨干,
161and in this case, fluorines on the edges而在这种情况下, 氟在边缘
162and an oxygen, hydrogen, you can have different moieties和氧气,氢气, 你可以有不同的杂质
163with different chemicals.与不同的化学品。
164But this eight carbon backbone,但是这八个碳骨干,
165Mother Nature didn't create this, okay?大自然不是创造的,好吗?
166Mother Nature doesn't have eight carbon backbones.大自然没有八个碳骨干.
167This is human created.这是人类创造的。
168And because of the novelty dating from the 1940s,由于1940年代的新颖之处
169we don't have a million years of coevolution我们没有百万年的共进主义
170with these products and bacteria that break them down.与这些产品和细菌 打破它们。
171So because of this lack of natural products因为缺乏天然产品
172that have adapted to eat this product,已经适应吃这个产品,
173there is nothing that breaks it down.没有什么能打破它。
174So it goes in the environment, stays in the environment,所以它进入环境 留在环境中
175and we call it a forever chemical我们称之为永远的化学
176because as far as we know, it's forever.因为我们知道,这是永远的。
177There is no breakdown product.没有分解产品。
178We're unaware of anything我们什么都不知道
179that will break this down in nature.这会打破这个自然。
180So it will simply be recycled within nature因此,它只是 自然界的循环
181and picked up by other organisms, including ourselves.并被其他生物,包括我们自己捡起来。
182Now these were transformative discoveries现在这些是变革性的发现
183that changed manufacturing and product development.这改变了制造业和产品开发。
184And many products were as a consequence of these chemicals.许多产品都是这些化学品的结果。
185So they were popular.所以他们很受欢迎。
186People said they were a breakthrough.人们说他们是一个突破。
187They were seen as a good thing.他们被视为一件好事。
188And we call them per and polyfluoroalkyl substances.我们称之为每个和多氟烷基物质。
189So they were used to make water, grease,所以他们用来制造水和油脂,
190and stain repellent clothing.和防污的衣服,
191So when I clumsily spill my coffee on my pants,所以当我轻轻地把咖啡洒在裤子上
192I'm dreading what the result will be我害怕结果会是什么
193when I go get some water当我去得到一些水
194because maybe I have stain resistant pants因为我有防污裤子
195and the next thing you know, it's clean.接下来的事情,你知道, 它是干净的。
196Maybe my sofa is stain resistant.或许我的沙发是防污的
197I clean it with water, it's clean.吾以水洗之,无毒.
198It's coffee, it should be brown.这是咖啡,应该是棕色的。
199Oh, it's fine.哦,没关系。
200So they're popular items, right?所以它们很受欢迎 对吧?
201You like it when it's stain resistant.你喜欢它防污
202And if you have water resistant clothing如果你有耐水服饰
203and you're going hiking or you're in a job你要么去远足 要么去工作
204where you're constantly being exposed to rain,在那里,你不断暴露 在雨,
205an outdoor job.户外工作
206And grease repellent coatings.还有防油涂层
207No stick cookware.没有棒的厨具。
208You make your egg and you just tip the pan你做你的鸡蛋,你只是小费锅
209and there it is on your plate instead of scraping it off.它就在你盘子里 而不是把它刮掉
210Now the US military said this here现在美军说在这里
211that Forever Chemicals are essentially永远的化学品本质上
212essential for military preparedness对军事准备至关重要
213because there were Congress persons saying因为有人说
214we should ban PFAS use to the US government.我们应该禁止美国政府使用PFAS。
215And the military people came in and said,军方进来说
216no, our torpedoes work better,不,我们的鱼雷工作更好
217our missiles work better with these substances.我们的导弹能用这些物质
218So they're powerful forces in industry, in government,因此,他们是强大的力量 在工业,在政府,
219不想摆脱PFAS。
220But this is what worries us in public health,但这是我们担心的 公共卫生,
221persistent in the body and the environment在身体和环境中长期存在
222at least for decades and maybe for hundreds of years,至少几十年,也许几百年,
223maybe thousands of years.也许几千年。
224We don't know yet because it's only been around我们不知道,因为只有周围
225since the late 1940s.从1940年代末开始
226So we know they don't degrade in 80 years, that we know.所以我们知道它们不会在80年后退化, 我们知道。
227And based on the chemist's judgment,根据化学家的判断
228they probably won't degrade for hundreds or thousands.他们可能不会降解 数百或数千。
229Now here are some products that contain PFAS.现在这里有一些包含PFAS的产品.
230Some grease-resistant paper,一些防油纸,
231fast food containers and wrappers,快速食品容器和包装,
232microwave popcorn bags.微波爆米花包装袋.
233You know how popcorn doesn't stick你知道爆米花不会粘的
234to your microwave popcorn bag.给您的微波爆米花包。
235That's a good thing, but it's thanks to PFAS.这是好事,但这要归功于PFAS.
236Pizza boxes, candy wrappers,披萨盒,糖果包装,
237you don't want your candy to stick to the wrapper,你不想让你的糖果 粘在包装,
238you can't get the candy out.你不能把糖果拿出来。
239That's happened to me, it's irritating.这发生在我身上,很刺激
240Half my candy ends up on the wrapper.我一半的糖果都放在包装上
241I like it, it's a slide right up.我喜欢,它是一个幻灯片右上。
242Non-stick cookware I mentioned, stain-resistant coatings,我提到的非棍子厨具 防污涂层
243carpets of whole three other factors,其他三个因素的地毯,
244water-resistant coatings, cleaning products耐水涂层、清洁产品
245and personal care products like shampoos, dental floss,以及个人护理产品,如假发、牙线,
246cosmetics like nail polish and eye makeup,比如指甲油和眼妆
247paints, varnishes, sealants and firefighter turnout gear.油漆、清漆、密封剂和消防员投票工具。
248You know, the stuff they put on before they go to the fire你知道,他们放的东西 他们去火前
249and firefighting foams.还有消防泡沫
250So, are these helpful, useful products?那么,这些有用的产品是有用的吗?
251Of course they are.当然
252Now, Teflon was introduced in 1946.现在,特夫隆于1946年被引入.
253And the PFOA used by DuPont to make Teflon杜邦制造特福隆用的PFOA
254and PFOS, these are relatives of PFAS,和全氟辛烷磺酸,这些是全氟辛烷磺酸的亲缘关系,
255was used by 3M Corporation to make Scotchgard.被3M公司用来制造苏格兰酒
256And the manufacture and importation of both of these和这两个的制造和进口
257have been, PFOS and PFOA have been banned in the US.美国已经禁止全氟辛烷磺酸和全氟辛烷磺酰氟。
258But they're still all around the world.但他们仍然在世界各地。
259Now, DuPont no longer makes or uses PFOA,现在,杜邦不再制造或使用PFOA,
260but Chemours is a spin-off corporation of DuPont但是Chemours是杜邦的附属公司
261and they make a replacement called GenX.他们做了一个叫GenX的替补。
262In the United States, we don't have federal regulation在美国,我们没有联邦条例
263of PFAS, so that means the states can regulate it也就是各州可以管理它
264if they want to.如果他们想的话
265And six states now have regulated it.而现在已有6个州对此进行了规范.
266So, six states have thought of PFAS as dangerous enough六个州认为PFAS足够危险
267that they would like to regulate.他们想管理。
268And 56 states have not regulated, 54 states,还有56个州没有管理,54个州,
26944 states have not regulated.44个州没有管制。
270My math is not good tonight.今晚我的数学不好
271So, serious drinking water contamination所以,严重的饮用水污染
272has been reported in China.在中国已有报告。
273And if you're interested in this,如果你有兴趣的话
274you can look up the article by Liu你可以看刘少奇的文章
275and per and polyfluoroalkyl substances, PFAS,和全氟烷基物质,PFAS,
276in Chinese drinking water risk assessment中国饮用水风险评估
277and geographic distribution.和地理分布。
278It's published in the Environmental Science Europe Journal发表在环境科学欧洲杂志上
279in 2021 and it's online.2021年上线.
280I downloaded it a couple of days ago and it's online几天前我下载了它 在网上
281and you can get it without difficulty.你可以不难地得到它。
282Now, some of the data from Liu,现在,一些数据来自刘,
283they obtained PFAS data from 526 drinking water samples,他们从526个饮用水样本中获得了PFAS数据,
28466 cities in China with almost half a billion inhabitants中国66个城市近5亿人口
285in these 66 cities.在这66个城市里
286And in more than one in five of the studied cities,在五分之一以上的城市里
287representing about 100 million people,代表大约1亿人,
288PFAS concentrations exceeded the levelPFAS 浓度超过水平
289by the state of Vermont,佛蒙特州,
290which is one of the earlier states that banned PFAS是较早禁止PFAS的州之一
291or regulated PFAS.或受管制的PFAS。
292They can't ban PFAS because it's in the environment他们不能禁止PFAS,因为它在环境中
293everywhere, they just ban the new use到处都是,他们只是禁止新的用途
294and then they have environmental standards,然后他们有环境标准,
295guidelines above which they deem a public health problem.他们认为以上是公共卫生问题。
296Now, human exposure to PFAS现在,人类接触PFAS
297were estimated using total daily intakes估计日摄入总量
298from a document called the Exposure Factors Handbook从名为《接触因素手册》的文件中
299of the Chinese population,中国人民,
300which has actually estimated water intake,它实际上估计了水摄入量,
301food intake from different populations all around China.中国各地不同人群的食物摄入量.
302Actually, it's a very interesting book.其实,这是本很有趣的书。
303And East China, which is where we are now,而东华,这就是我们现在的位置,
304and the Southwest regions are at relatively higher risk西南地区的风险相对较高
305of having high PFAS, which makes sense.有高的PFAS,这是有道理的。
306Where is the manufacturing?生产在哪里?
307Where is the consumption?消费在哪里?
308Where is the population the densest?人口密度最高的地方在哪里?
309Now, some cities in the Yangtze River Basin,现在,长江流域的一些城市,
310Zhejiang, Zhujia, Lian, Yungang,浙江诸暨人,莲,云冈人.
311and others have exceeded European Union其他国家已超过欧洲联盟
312and US health guidance.和美国卫生指导。
313So this team of Chinese scientists所以这个中国科学家团队
314is trying to ring the alarm bell想要敲响警钟
315as to PFAS concerns in your country.关于《方案》对贵国的关切。
316Now, what about human health?现在,人的健康呢?
317That's the only thing I know about.这是我唯一知道的
318Everything else I've shown you其他一切我都给你看了
319is what my engineers have taught me.那是我的工程师教我的
320So we've learned that PFAS is associated所以我们知道PFAS是有联系的
321with a variety of cancers,患有各种癌症,
322testicular, kidney, liver, and pancreatic,睾丸 肾脏 肝脏 胰脏
323increased cholesterol,胆固醇增加,
324harmful effects to developing fetus对胎儿发育的有害影响
325and breastfeeding infants,和哺乳婴儿,
326low infant birth weights,婴儿出生体重低;
327effects on the immune system and thyroid gland,对免疫系统和甲状腺的影响,
328and weight gain in humans.和体重的增加 人类。
329And I was happy when I came to Beijing我来到北京时很开心
330because my colleague, Professor Hu Yifei,因为我的同事胡一飞教授
331is going to be working on some of the childhood effects正在研究一些 童年影响
332and taking a look in her Beijing pediatric cohort看着她的北京儿科
333study, she'll be looking at this question学习,她会看着这个问题
334with one of her students.和她的一个学生
335And so what links, these look like very diverse所以,什么链接, 这些看起来像非常多样化
336health problems, don't they?健康问题,不是吗?
337But what system in the body might link them, do you think?但身体里有什么系统可以把它们联系起来 你觉得呢?
338What is the heart and cholesterol and infant weight心脏、胆固醇和婴儿体重是什么?
339and the immune system, the thyroid,和免疫系统,甲状腺,
340and the testicles and weight gain,以及睾丸和重物,
341what do they have in common?他们有什么共同点?
342Yeah, you could say that because I wouldn't agree是啊,你可以这么说 因为我不同意
343with either big question, which is the endocrine,无论是大问题, 内分泌,
344the endocrine system.内分泌系统。
345So we'll get to that in a minute.所以,我们会得到在一分钟。
346So what we have here is EPA health advisories我们这里有环保局的健康建议
347are at 0.07 micrograms per liter.每升0.07毫克。
348There's no maximum containment level for drinking water.饮用水没有最高封存水平.
349It's not listed as a hazardous waste它不列为危险废物
350with these two big groups.和这两个大团体。
351And different nations have different PFAS values.不同的国家有不同的PFAS价值。
352So the point I'm making is we don't have所以我想说的是 我们没有
353a global consensus on PFAS.全球共识。
354We don't have global guidelines我们没有全球准则
355that WHO has recommended.卫生组织的建议。
356We don't have the European countries我们没有欧洲国家
357and the Americans and the Australians and the Chinese美国人、澳大利亚人、中国人
358and the Indians are not all agreeing.而印度人并不都认同
359So we're still learning.所以我们还在学习。
360And some states are adopting more stringent endpoints now有些州现在采取更严格的终点
361because they're more worried.因为他们更担心
362So, you know, there are oldies with goodies like cast iron.所以,你知道,有老人 有像铸铁这样的好东西。
363So cast iron, which also is pretty good at not sticking,所以,铸铁, 也相当擅长不粘,
364doesn't have PFAS because the way they cast the iron,没有PFAS 因为他们投铁的方式,
365the steel, if you will,钢,如果你愿意,
366is such that PFASs are not necessary.因此,没有必要制定行动建议。
367And copper, if you use copper like Revere ware,和铜,如果你使用 铜像里维尔沃雷,
368and there's a copper base that also is not using PFAS,还有一个铜基 也没有使用PFAS,
369but it's gaining some of the same benefits但它得到了一些相同的好处
370of not being stick.没有被坚持。
371Now exposure routes, drinking contaminated water,现在暴露路线,饮用水污染,
372it can be municipal, it can be well,它可以是市政, 它可以是很好,
373it can even be bottled.它甚至可以装瓶。
374Eating fish caught from water contaminated by PFAS食用被PFAS污染的水捕获的鱼
375or PFAS in particular,或特别是行动建议,
376accidentally swallowing contaminated soil or dust,无意中吞噬了被污染的土壤或尘埃,
377eating food that was packaged in materials with PFAS食用用PFAS材料包装的食物
378and using some consumer products like non-stick cookware,并使用一些消费产品,如非棒的烹饪器械,
379stain-resistant carpeting, water repellent clothing.防污地毯,防水服装
380Now here's some good news.现在有个好消息
381Only small amounts of PFAs can get through skin.只有少量的PFA才能通过皮肤.
382Showering, bathing, washing dishes洗澡、洗澡、洗碗
383is not getting increased exposure in any substantial way.并没有以任何实质性方式增加接触。
384So you don't have to go around being totally paranoid.所以,你不必到处走 完全偏执。
385That's PFAS contamination in the United States.美国的PFAS污染。
386It's concentrated where the population density它集中在人口密度
387is the greatest, where manufacturing is the most intensive,是最大的, 在制造业是最密集的,
388and you can see that it's nationwide.你可以看到它是全国的。
389Now fire retardants include polybromelated diphenyl ethers现在阻燃剂包括多溴化二苯醚
390and these are considered persistent organic pollutants.这些被认为是持久性有机污染物。
391They're not forever chemicals.它们不是永远的化学物质。
392They do break down, but they take a very, very long time.它们确实崩溃了,但它们需要很长的时间。
393They're used in furniture, carpets, vehicles, electronics,它们被用于家具,地毯,车辆,电子,
394and they show up in sediment, water, and air.它们出现在沉积物、水和空气中。
395Very easy to detect them.非常容易发现它们。
396Penta and octoforms have been phased out,五角星和八角星已经淘汰,
397but the deca is still used.但十进制仍然被使用
398And these so-called organophosphate substitutes这些所谓的有机磷酸盐替代品
399are showing up in blood too.血流成河
400Now we think they can cause fertility problems现在我们认为它们会引起生育问题
401and are linked to poor cognitive function in children.并且与儿童认知功能不良有关。
402A nickname is Tris.一个绰号是Tris.
403You may have heard of Tris.你可能听说过Tris
404And these leaching out of products,而这些沥出的产品,
405getting into blood by drinking, eating,喝酒、吃饭、进血
406touching, or inhaling, children and pets have more exposure接触或吸入儿童和宠物的接触量增加
407because they have more hand-to-mouth activity,因为他们有 更多的手对嘴活动,
408children do, and pets are on the ground all the time.孩子们会的 宠物总是躺在地上
409Now the concern is that these are endocrine disruptors.现在的问题是,这些是内分泌干扰物。
410Endocrine disruptors.内分泌干扰剂
411It's the endocrine system that pulls together是内分泌系统凝聚在一起
412some of those diseases I was telling you about.我跟你说过的一些疾病
413There may be a carcinogenicity,可能有致癌性,
414may cause liver, thyroid, and neurodevelopmental function,可能导致肝脏、甲状腺和神经发育功能,
415and it accumulates in the body.它会积累在体内。
416This is an interesting reference这是有趣的参考文献
417that I just found this morning.我今早才发现的
418It's PBDE and PFAS.是多溴联苯醚和多溴联苯醚。
419So they studied the fire retardants他们研究了阻燃剂
420and the forever chemicals during pregnancy孕期的化学品
421and maternal depression,和产妇抑郁症,
422published in Environment International.发表于环境国际。
423And what they said was there was a very strong correlation他们说有很强的关联性
424between blood levels of the PBDE and oral blood.多溴二苯醚的血液水平与口服血液之间。
425Or the PFAS with pregnancy-related depression.或者PFAS 与妊娠有关的抑郁症。
426Now it'll take a lot more research to prove that,现在需要更多的研究来证明
427but it certainly was an interesting hypothesis但它当然是一个有趣的假设
428being generated.正在生成。
429And that's why I'm talking about chemicals这就是为什么我谈论化学
430that are not forever chemicals, but they're related,并不是永远的化学物质, 但它们是相互关联的,
431so I think you should know something about them.所以我觉得你应该了解他们
432Now the endocrine system, as almost all of you know,现在,内分泌系统, 几乎所有人都知道,
433are the glands that produce是产生腺体的
434and secrete hormones in our body,还有我们体内的分泌激素
435regulating growth, metabolism,调节生长,代谢,
436sexual development and function,性发展和功能,
437and also the emotions.还有情感
438And the pituitary gland, the hypothalamus,还有垂体腺 下丘脑
439the thyroid gland, parathyroid, adrenal gland,甲状腺 甲状腺 肾上腺
440pineal body, or pineal body as it's sometimes pronounced,松体,或者松体 因为它有时被宣告,
441and reproductive glands like the ovaries and testes以及卵巢和睾丸等生殖腺
442and the pancreas.和胰脏。
443These are the endocrine system at work.这些是工作上的内分泌系统。
444So endocrine disrupting compounds所以内分泌干扰化合物
445is a synthetic chemical that either mimics是一种合成化学物质,要么模仿
446or blocks hormones.或阻塞荷尔蒙。
447So it can either mimic a hormone,所以可以模仿荷尔蒙
448it can resemble a hormone, or it can block a hormone.它可以像激素, 或者可以阻断激素。
449So it either can facilitate exaggeration这样也可以方便夸张
450of an endocrine signal,内分泌信号,
451or it can inhibit an endocrine signal.或者可以抑制内分泌信号
452So different PFAS compounds不同的PFAS化合物
453and other endocrine disrupting compounds及其他干扰内分泌的化合物
454can do one or the other.可以做一个或者另一个。
455And some of them are environmental,有些是环保的,
456like oak leaf trees have endocrine disruptive compounds.就像橡叶树有干扰内分泌的化合物
457They're natural.它们很自然
458But nobody lives in an oak leaf tree bed.但没有人住在橡树树床上
459Nobody sleeps with oak leaves scattered on their pillows.枕头上散落着橡树叶 没人会睡觉
460I mean, you know, none of us are exposed to oak leaves我的意思是,你知道, 我们没有人接触橡树叶
461in any substantial way.以任何实质性的方式。
462Decaying matter, plant matter,衰变物质 植物物质
463also can produce some of these.也可以产生其中的一些。
464And plants with natural products called phytoestrogens.还有天然产品的植物 叫做植物学
465And you can read about phytoestrogens.你可以读到关于植物群。
466有许多植物具有植物estrogens.
467And there's some funny vegetables还有一些有趣的蔬菜
468that if you eat a ridiculous,如果你吃一个可笑的,
469like if I eat carrots all day long for the next three days,就像我整天吃胡萝卜 在接下来的三天,
470my body will turn yellow.我的身体会变黄
471Because I'm eating all these carrots.因为我在吃这些胡萝卜
472People will think I'm jaundiced.人们会认为我被愚弄了
473But my eyes won't turn yellow.但我的眼睛不会变黄
474这就是Jaundice的区别
475from hypercarotidemia versus jaundice, real jaundice.超焦血症和真黄油
476The eyes turn yellow in jaundice,眼睛变黄了
477but not with eating too many carrots.但不是吃太多胡萝卜
478That's an obscure point for medicine.这是医学的一个模糊点。
479Now, we have all of these compounds,现在,我们拥有所有这些化合物,
480household cleaners, personal care products,家庭清洁工、个人护理产品、
481pharmaceuticals, pesticides, processed foods,药品、农药、加工食品、
482plastics, industrial chemicals,塑料、工业化学品、
483animal and veterinary sources,动物和兽医来源,
484air deposits of fire retardants.空气中的阻燃剂。
485They're all on this list.他们都在这个名单上。
486So if you go to the Environmental Protection Agency如果你去环保局
487of the US government,美国政府,
488there's a list of endocrine disruptors,有一个列表 内分泌干扰,
489and there are more than 12,000 chemicals.还有超过12,000种化学品。
490Now, most of them that you are exposed to现在,大多数你接触到的
491in very low amounts数额极低
492are not going to overwhelm your endocrine system.不会超过你的内分泌系统。
493But if you have a strange diet or a certain type of job,但是,如果你有 奇怪的饮食或某种类型的工作,
494and you're exposed to a lot of these,你接触到很多这些,
495it could disrupt your endocrine system.可能会扰乱你的内分泌系统
496And they have this endocrine disruptor screening program.他们有内分泌干扰检查计划
497So some products contain this statement in the US,所以有些产品 在美国有这个声明,
498do not use if you're pregnant or breastfeeding,怀孕或哺乳时不要用
499do not expose children under five years of age.不暴露5岁以下儿童。
500That often indicates that the product contains这往往表明产品含有
501endocrine disrupting compounds.内分泌干扰化合物.
502And in California, they have a warning在加利福尼亚,他们有一个警告
503that is required to be put on such products(b) 需要将这些产品上加装;
504that it says,它说,
505this product may contain a chemical该产品可能含有一种化学品
506known to the state of California加利福尼亚州
507to cause cancer or birth defects致癌或先天缺陷
508or other reproductive harm.或其他生殖伤害。
509So some places are trying to alert consumers,有些地方想提醒消费者
510but most consumers, I think it's fair to say,但大多数消费者,我认为说,
511are clueless about endocrine disrupting compounds.对干扰内分泌的化合物一无所知
512Now, endocrine disrupting compounds现在,内分泌干扰化合物
513are especially harmful for children.对儿童特别有害。
514They can cause dyslipidemia,可能会引起血滑症
515obesity, compromised renal function,肥胖,肾功能受损,
516and less vigorous or dysfunctional immune responses.和较不有力或功能失调的免疫反应。
517I've read several papers about children我读过好几篇关于孩子的论文
518who have high levels of endocrine disrupting compounds内分泌干扰化合物含量高的
519who don't respond to vaccines as vigorously他们对疫苗的反应并不强烈
520as a normal child would.就像一个正常的孩子一样
521And you can exacerbate asthma risk.你可以加剧哮喘的风险。
522Because asthma, of course, is an autoimmune phenomenon当然,哮喘是一种自体免疫现象
523where the lungs are receiving signals肺部接收信号的地方
524that sort of result in hyper constriction.导致过度收缩
525And if you disrupt the endocrine system,如果你扰乱内分泌系统
526that can be exacerbated.这可能会加剧。
527现在,幼年的menarche。
528Menarche may not be an English language wordMenarche 可能不是一个英语单词
529that's familiar to all of you.这是大家熟悉的。
530So that's the time when a girl gets her period,因此,这时候 一个女孩得到她的月经,
531starts her menses.开始她的月经。
532So menarche, when I was a boy,我小的时候,很温柔
533was typically at about 13 years of age.年龄一般在13岁左右。
534But by the time, I was in the 1950s.但到那时,我在1950年代.
535By the time the 1970s came around1970年代的时候
536and I was in medical school,我在医学院,
537menarche was more like 11 years,更像是11年,
538two years faster than when I was a kid.比我小时候快两年
539And by the time I reach Beijing in November of 2023,到2023年11月我到达北京时
540a lot of papers are coming out with menarche有很多报纸会刊出
541at nine, 10, eight.在九、十、八点
542So it is a phenomenon of the late 20th century,所以这是20世纪后期的一种现象,
543early 21st century, that girls all around the world21世纪初,全世界女孩
544are having their periods at a younger age.年幼时有期。
545And it is widely thought,人们普遍认为,
546and here's some references here.这里有些参考文献
547Rapazzo is in International Journal of Environmental拉帕佐在《国际环境杂志》上
548Research and Public Health, 2017,研究和公共卫生,2017年,
549a nice systematic review.一个很好的系统审查。
550I had a few, I have a few of this article.我有一些,我有一些这篇文章。
551I brought some photocopies.我带来了一些影印件。
552I put them out front, maybe some of you got a copy.我把它们放在前面,也许你们有些人有副本。
553But you can get it online.但你可以上网
554And there's a toxicology report.还有毒理学报告
555So, you know, what is the effect of a girl所以,你知道,什么是 效果一个女孩
556having her period earlier?她早点来了吗?
557We don't really know.我们不知道
558Is this harmful?这有害吗?
559Well, for one thing, she can get pregnant earlier.首先 她可以早点怀孕
560So if she's raped or abused or something,所以,如果她被强奸或虐待什么的,
561she can get pregnant earlier.她可以早点怀孕
562But there may be psychological effects.但可能会有心理影响.
563You become a woman when you're nine years old,你九岁就变成女人了
564instead of 13 or 14.而不是13或14个。
565So there are all sorts of potential issues here.所以这里有各种各样的潜在问题。
566And if what many of us suspect,如果我们中很多人怀疑什么
567which is that this is due to endocrine disrupting compounds,这是因为内分泌干扰化合物,
568by far the best hypothesis.这是目前为止最好的假设
569Nobody else has a good hypothesis of why this has happened.其他人对为什么会发生这种情况没有很好的假设。
570People say good nutrition.人说好营养.
571Well, there were plenty of people that had good nutrition有很多人营养很好
572in the 1940s and 1930s, had perfectly good nutrition.在1940年代和1930年代, 营养完全良好。
573But they didn't have their periods of nine,但他们没有9岁
574they had their periods when they were 14.他们14岁时有月经
575So anyway.总之
576Now, there are many other micro constituents,现在,还有许多其他的微成分,
577including things like plastics,包括塑料等东西,
578microplastics and microbeads.微塑与微珠.
579So plastics disintegrate into the land and into the oceans.因此塑料会分解成陆地和海洋.
580And if they get into the oceans,如果他们进入海洋,
581or the lakes or the rivers,或湖泊,或河流,
582they're ingested by aquatic organisms,它们被水生生物吞噬
583because they're breaking down into microplastics.因为他们正在分解成微塑胶
584And microplastics just get eaten和微塑料只是被吃
585and filtered by the fish and other creatures.被鱼和其他生物过滤
586So many这么多
587personal compounds,个人化合物,
588personal use compounds,个人用途化合物,
589contain microbeads like exfoliates含有类似叶片的微生物
590or body washes or toothpastes.或身体洗涤或牙膏。
591If you buy a toothpaste如果你买了牙膏
592that says special whitening ingredient,上面写着特殊的白化成分
593that's all often these microbeads.这都是这些微生物。
594Because microbeads will not hurt your enamel.因为微生物不会伤害你的蛋白质
595But most other,不过其他的
596most other products will scratch your enamel.大多数其它产品会刮伤你的蛋白质。
597So the dentists don't want you to use these,所以牙医不希望你用这些
598but microbeads won't.但微生物不会。
599So they're allowed.所以他们被允许。
600And body washes, my body wash is the best on the market.和身体洗涤,我的身体洗涤是最好的市场。
601You'll be cleaner.你会更干净的。
602Well, sometimes microbeads are a gentle,嗯,有时微珠是温柔的,
603a gentle scrubbing action.一个温柔的洗涤动作。
604And exfoliates are,叶片是,
605are products sold specifically to take skin off.是专门出售用来脱皮的产品。
606And humans who ingest seafood like me,还有吃我这种海鲜的人
607because I'm of Norwegian descent,因为我是挪威后裔
608so I eat a lot of seafood,所以我吃了很多海鲜,
609also take in up to 11,000 tiny,最多可达11,000微米
610tiny pieces of plastic every year,每年有一小块塑料
611just by eating our fish.只是吃我们的鱼。
612And in the U.S. since 2017,而在2017年起的美国,
613it's been illegal to sell personal care products,卖个人护理产品是违法的
614PCPs with plastic microbeads.含有塑料微生物的五氯苯酚。
615But at the rest of the world,但在世界其他地方,
616it's much of the rest of the world is perfectly legal.世界上大部分地方都完全合法
617And the next challenge is glitter,下一个挑战就是闪耀
618which are just small pieces of plastic.这些只是小块塑料。
619So glitter is used for all sorts of things,所以闪光是用来做各种事情的
620celebrations, weddings, happy things.庆祝,婚礼,快乐的东西。
621You have glitter.你有闪光。
622And you even see it in,你甚至看到它在,
623in, in cosmetics nowadays.在化妆品里
624And now here's a larval perch.现在,这里是一个幼虫坑。
625What's a perch?何为彼施.
626per(学名:Perch)为 this魚 small形目 freshwater科 small属的鱼类,是有关这种大淡水鱼的小鱼类.
627It was very common in my home state of Wisconsin这在我家乡威斯康辛州很常见
628when I grew up as a kid.当我从小长大
629I used to go fishing.我曾经去钓鱼。
630I'd fly, I'd, I'd get perch.我会飞的,我会飞的,我会飞的
631Very tasty.好吃极了,你觉得呢?
632And there are perch relatives all over the world.而世间有百灵亲.
633And so this is a larval perch, the baby perch.这是幼虫的腹部,婴儿的腹部。
634And look at all the beads.及观一切珠.
635Now, those beads are not recognized现在,这些珠子不认得了
636由perch的系统。
637It's, it's GI system.这是,这是GI系统。
638They're not, they're not food.他们不是,他们不是食物。
639So they just sit there.所以他们只是坐在那里。
640And when the perch grows up to be a fish perch,当鱼笼长成鱼笼
641instead of a larval perch,而不是一个幼虫perch,
642then the beads are still there and maybe a lot more beads.然后,珠子还在那里 也许更多的珠子。
643Microplastics and microfibers.微塑料和微纤维.
644Did you know that, that microfibers are made of plastic你知道,微纤维是塑料做的吗?
645and chemical-covered non-plastics?和化学覆盖的非塑料?
646So a lot of the products, nylon, rayon,所以很多产品,尼龙,瑞昂,
647all of these polyester products,所有这些聚酯产品,
648like the stuff I'm wearing, I guess,就像我穿的东西,我想,
649maybe the stuff you're wearing,也许你穿的东西,
650have a lot of plastics in them.里面有许多塑料
651I did not know this a year ago.我一年前不知道这一点。
652I'm trying to educate myself about this.我试图教育自己 关于这一点。
653It was mind-boggling how many plastics多么令人惊奇的塑料
654have an origin from our clothing.从我们的衣服里找到的
655I didn't know this.我不知道这一点。
656So I figured if I didn't know it,所以我想如果我不知道的话
657maybe you didn't know it and I could share it with you.也许你不知道 我可以跟你分享
658So what happens is it breaks off clothes in the water事情是这样的,就是在水里脱掉衣服
659when you wash it and it's discharged through the drain water.当你把它洗掉,然后从排水口排出。
660And you never see it because it's in the washing machine.你从没见过它,因为它在洗衣机里。
661Or even if you're doing it by hand,或纵以手作.
662it goes down the drain.它会下水道。
663You don't see it.汝不见.
664They're microfibers.他们是微纤维。
665Now one fleece jacket alone现在单挑一件夹克
666can shed 250,000 pieces of fiber per wash.每洗一洗就可丢掉25万块纤维
667Here's a tangle of microfibers这是微纤维的缠圈
668that were filtered from drain water.是从排水中过滤出来的
669Standard load of laundry.标准负荷的洗衣。
670The human hair is about 70 microns.人类的头发约为70微米.
671The naked eye can see about half of a human hair.肉眼可以看到大约一半的人毛.
672A red blood cell is about eight microns.红血球约为8微米.
673And microfibers vary between three and 60 microns.而微纤维在3至60微米之间变化.
674So only a fraction of them are visible.所以只有一小部分是可见的。
675Most of them are invisible.其多为无形.
676Another category, bisfinite phenol A or BPA另一种类别,双极酚A或溴代苯A
677are used in clear, hard plastics.用于清晰的硬塑料。
678Polycarbonate plastic and epoxy resins since the 1950s.1950年代起的聚碳酸酯塑料和环氧树脂.
679They have weak hormone-like properties.它们的激素性能很弱
680So they're also potential endocrine disruptors.因此它们也是潜在的内分泌干扰物.
681Some U.S. states have laws to prohibit BPA一些美国州有法律禁止BPA
682from being used in baby bottles and products用于婴儿瓶和产品
683because we don't know what effect it'll have in babies.因为我们不知道它对婴儿有什么影响
684So why are we using plastic baby bottles?我们为什么要用塑料婴儿瓶?
685We should be using glass baby bottles.我们应该用玻璃婴儿瓶
686Or breast milk is even better.或者母乳会更好
687And many manufacturers have made substitutions.并且许多制造商也制造了替代品.
688So a lot of manufacturers are changing their product line所以很多制造商都在改变他们的产品线
689to make sure there's no BPA.以确保没有BPA。
690Now removal is difficult.现在移除是困难的。
691Replacement products have to either be corrosion-resistant替代产品必须耐腐蚀
692to withstand high temperatures.能够承受高温
693Use for sterilization processing.用于绝育处理。
694Be chemically compatible with foods.与食物化学相容.
695Not add odor or taste,不增加气味和味道,
696which was the big advantage of the BPAs.这是BPA的优势。
697So reducing exposure by using glass baby bottles,因此,通过使用玻璃婴儿瓶减少接触,
698stainless water bottles,不锈水瓶,
699food products not in cans rather than plastic.食品不是罐头而是塑料制品。
700I have tried to stop drinking from plastic.我试图停止喝塑料。
701Just as I have.就像我一样
702So in the hotel, I take my tea所以在酒店,我拿我的茶
703kettle and I boil the water水壶和我煮水
704and then I pour it into my glasses然后我把它倒进我的眼镜
705and I drink that instead.我喝这个代替。
706Now I'm not protecting myself from PFAS现在,我不是在保护自己不受PFAS的伤害
707because that might come from this water or that water,因为可能来自水或水,
708but there are plenty of things但有很多东西
709that I am protecting myself from我是在保护自己
710by not drinking or eating from plastic goods.不喝不吃塑料制品
711But let me tell you, it's almost impossible.但我告诉你 这几乎是不可能的
712It's very, very difficult to avoid plastic.非常,非常难避免塑料。
713But I do it whenever I can,但我只要能做到这一点,
714which still is a small, small thing.这还是一件小事
715Phthalates, phythalates 我们称之为各地的化学。
716Not the forever chemical, but the everywhere chemical不是永远的化学,而是各地的化学
717because they're in so many different products.因为他们在很多不同的产品。
718They don't last as long as PFAS, thank God.他们不会持续到PFAS,感谢上帝。
719They're in soft plastic toys.他们在软塑料玩具。
720They're in vinyl flooring and wall covering.它们在阴道地板和墙壁覆盖。
721New car smell is a phthalate smell.新车味是一种邻苯二甲酸盐味.
722Detergents, lubricating oils, food packaging,洗涤剂、润滑油、食品包装
723pharmaceuticals, blood bags and tubing in the hospitals.药品 血袋 医院的管子
724And about 75% of personal care products,大约75%的个人护理产品,
725cosmetics, fragrances, nail polish, hair sprays,化妆品 香料 指甲油 头发喷雾
726soaps, shampoos have these phthalates.肥皂,香皂有这些邻苯二甲酸盐.
727Now, what about a phthalate?现在,什么是邻苯甲酸盐?
728Why are we concerned?我们为什么要担心?
729Well, it's still that endocrine disruptor function内分泌干扰器的功能
730that we're concerned about.我们很担心
731Now, many manufacturers in the US and Europe现在,美国和欧洲的许多制造商
732are taking phthalates out of products正在从产品中取出邻苯二甲酸酯
733because customers have complained.因为顾客抱怨过
734Do I have to have these phthalates in the product?产品中必须含有这些邻苯吗?
735How critical are they?他们有多重要?
736They're so ubiquitous.他们无处不在。
737So Avon, Johnson & Johnson, Revlon, even Disney.因此,阿文,约翰逊&约翰逊,雷弗龙,甚至迪士尼.
738They make a lot of toys, Disney.他们做了很多玩具,迪士尼。
739And if you want to check if phthalates are in products,如果你想检查邻苯二甲酸酯是否在产品中
740you can go to this website, ewg.org, skin deep.你可以去这个网站,ewg.org,皮肤深。
741And there's a phthalates action plan summary还有邻苯二甲酸盐行动计划摘要
742from the US Environmental Protection Agency.美国环境保护局的
743They did it about 11 years ago.大约在11年前
744You can read about that.你可以读到这一点。
745And the Department of Environmental Health Policy环境卫生政策部
746is testing for public water supplies正在测试公共供水
747and regulating under the Safe Drinking Water Act根据《安全饮水法》进行管理;
748in the United States.在美国。
749Pharmaceuticals, another list of chemicals药品,另一个化学品清单
750that get into the environment at high rates.高速度进入环境。
751People throw away drugs that they haven't used人们扔掉他们没有使用的毒品
752into the sink or toilet.进入水槽或厕所。
753And public sewer systems and septic systems还有公共下水道系统和化粪池系统
754end up at wastewater treatment plants, don't they?最后在废水处理厂,不是吗?
755People throw the drugs into the trash.人们把毒品扔进垃圾桶
756And these medications, those medications这些药,那些药
757that are applied externally外部应用
758are discharged during showering, bathing, and hand washing.在洗澡、洗澡和洗手时出院。
759So I had a little rash from my jogging,所以我慢跑时有点疹子
760and I used a hydrocortisone cream.我用的是氢丙酮奶油。
761So that's fine.所以,这是罚款。
762Then my rash went away.然后,我的皮疹消失了。
763But where did the hydrocortisone product go?但氢丙酮产品去哪了?
764When I took a bath or shower, it went into the water.当我洗澡或淋浴时,它会掉进水里.
765And if I washed my clothes, it went into the water.如果我洗了衣服,它会掉进水里
766So, you know, use your imagination.所以,你知道,用你的想象力。
767Now here's a real shocker.现在有一个真正的震惊者。
768If any of you are physicians, you may be aware of this,如果你们中有人是医生 你们可能会知道
769but most of you who are not physicians你们大半不是医生,
770probably don't know this.也许不知道这一点。
771But we only metabolize a fraction但我们只是代谢了一小部分
772of the drugs that we put in our body.我们放进体内的毒品
773Sometimes the bioavailability is very high有时生物利用率很高
774and we'll metabolize 90% of the product,我们会代谢90%的产品,
775and we only excrete 10% of it.我们只排出10%的粪便
776Sometimes the bioavailability is not very high,有时生物利用率并不高
777and it's the other way around.和它的另一边。
778We only metabolize 10% of it, and we excrete 90%.我们只代谢了10%,我们排出90%。
779Just a little aside,稍微靠边
780would any of you care to guess anesthetic gases你们谁愿意猜测麻醉气体
781that we then inhale to be put to sleep for surgery?然后我们吸气 睡觉做手术?
782How much of that gas is metabolized by our body多少气体被我们的身体所代谢
783and puts us to sleep, and how much of it is exhaled?使我们入睡,其中有多少是吸入的?
784Anybody want to guess, is it 95% of it used?有人想猜吗 95%是用过的吗?
785Is 50% of it used?50%是用过的?
786Is 5% of it used?5%是用过的吗?
7875% is used.使用5%。
78895% we simply blow out again.95%,我们只是再次爆炸。
789And interestingly, anesthetic gases,有趣的是,麻醉气体,
790some of them are potent greenhouse gases.其中一些是强烈的温室气体。
791So enlightened anesthesiologists and environmentalists如此开明的麻醉师和环境学家
792have worked with industry now for gas recapture systems.已经与工业合作 天然气回收系统。
793So instead of venting these gases,因此,与其排放这些气体,
794they're now being re-harvested and processed他们现在被重新收割和加工
795so they don't end up in the environment这样他们就不会在环境中
796contributing to global warming.造成全球变暖。
797That was not anything to do with this talk,这和这次谈话无关
798but sort of an analogous issue.但有点类似问题
799Now how do we reduce pharmaceuticals in the environment?现在怎样减少环境中的药品?
800We have to educate the public我们要教育公众
801to dispose of medications properly.正确处置药物。
802That's how we reduce it.这就是我们如何减少它。
803Because in the US, we have drug take-back events因为在美国,我们有毒品回收事件
804that are announced, and people can dispose宣布,人们可以处理
805in an authorized collection box at a pharmacy在一个药店授权的收藏箱里
806or at these drug take-back events.或在这些毒品收回事件。
807And collected drugs are ultimately incinerated,收集的药物最终被焚毁
808which is a way to just get rid of them in the environment.这是在环境中摆脱他们的方法。
809And trash notifications to remind people和垃圾通知提醒人们
810not to throw away their pharmaceuticals in the trash不要把药扔进垃圾桶里
811are often written in English, Spanish, and Chinese经常用英文、西班牙文和中文写成
812in the US, the three most common languages.在美国,三种最常见的语言。
813And if possible, you can reduce the amount that you ingest,如果可能的话 你可以减少摄入量
814medications and nutraceuticals or dietary supplements.药物和营养素或膳食补充剂。
815Only take the medications that are appropriate.只服适当之药.
816Don't take medications longer than you need to.别吃药太久了
817And have your doctor review the medications让你的医生检查药物
818and supplements that you take.并补充你需要的。
819I have friends who take dietary supplements every day我有朋友每天吃减肥药
820that they don't need.他们不需要。
821They have a balanced diet.他们的饮食平衡
822They don't need supplements.他们不需要补充
823Women might need iron if they're menstruating.女人要是月经要用铁
824They might need vitamin D.他们可能需要维生素D。
825But otherwise, most people don't need anything.但除此以外,大多数人不需要任何东西.
826A balanced diet, you don't need to take these things.平衡的饮食,你不需要服用这些东西。
827On the other hand, very large industries另一方面,非常大的工业
828are trying to sell a lot of products,想要卖很多产品
829and all this stuff ends up in the environment所有这些东西都发生在环境中
830one way or the other.一种或另一种方式。
831And what do we contribute from pharmaceuticals,我们从药品中能贡献什么
832I spelled it wrong, and personal care products?我拼错了,还有个人护理产品?
833In way back 15 years ago,早在15年前,
834the average person in the US used nine a day.美国的平均人每天用9个
835The most recent number is 15.最近的数字是15。
836So that's 15 pharmaceuticals or personal care products15种药品或个人护理产品
837per person per day, which includes drugs,每人每天,包括毒品,
838supplements, lotions, soaps, gels, powders,补充剂、乳液、肥皂、凝胶、粉末、
839clothes, sprays, toothpaste, makeup, medications.衣服、喷雾剂、牙膏、化妆品、药品
840So think about every product or medication想想所有的产品或药物
841you use this week, and it's a lot.你用这周,这是很多。
842I did it as an exercise the other day,前几天我做运动的时候
843and I got up to 14.我得到了14岁。
844And I'm not a big consumer really,我也不是个大消费者
845and I usually don't use makeup.我通常不化妆
846That's a joke.开个玩笑
847So remember, everything goes somewhere.所以,记住,一切去的地方。
848Do you need to use all these things?你需要用这些东西吗?
849Can you substitute something less toxic to the environment?你能代替对环境毒性较低的东西吗?
850And especially, can you reduce antibacterials that you use?特别是,你能减少你使用的抗菌药吗?
851We don't like people taking antibiotics我们不喜欢吃抗生素
852when they're not necessary.当它们没有必要的时候。
853We don't like people using antibacterial creams我们不喜欢别人用抗菌霜
854when they're not necessary,当它们没有必要的时候
855because it introduces antibiotics into the environment,因为它将抗生素引入环境,
856which can stimulate drug-resistant mutations可以刺激抗药突变
857in bacteria and selection.在细菌和选择。
858So microconstituents are everywhere.故微形体无处不在.
859All municipal sewage in the world世界所有城市污水
860contains microconstituents.包含微结构。
861Different geographic areas will differ不同的地理区域将不同
862with respect to the types, quantities,关于类型、数量、
863and relative abundance, of course.当然还有相对的丰富
864Microconstituents can be transported by water,微结构物可以通过水运输,
865food, touch, and air.食物,触摸,还有空气
866They are found in all tested waterways,它们存在于所有经过测试的水道中,
867and are found in drinking water, both tap and bottle.水龙头和瓶子里都有
868Presence of a microconstituent存在微观结构
869doesn't necessarily mean it's harmful.不一定意味着它有害。
870And that's why we have an environmental health sciences这就是为什么我们有 环境卫生科学
871department at the Yale School of Public Health.耶鲁大学公共卫生学院系.
872That's why the U.S. has an environmental protection agency.因此美国设有环境保护机构.
873That's why China has its这就是为什么中国有它
874environmental protection administration,环境保护行政部门,
875because we need groups like this因为我们需要这样的团体
876to do and interpret needed research,进行和解释必要的研究,
877to try to find out what's dangerous, what's not.试着找出什么是危险的,什么不是。
878Because it's unrealistic to say,因为说不现实
879I want to get rid of microconstituents.欲除微结.
880It's not possible.这是不可能的。
881So we have to figure out which ones are dangerous,所以我们要找出哪些是危险的
882and try to get rid of those.试着摆脱这些。
883Now, I want to end, well, plastic recycling, by the way,现在,我想结束 塑料回收,顺便说一句,
884threes and sevens are the worst products.三七产品最差.
885So if you can avoid buying things如果你能避免买东西
886that have threes and sevens on them, you'll do well.上面有3和7,你会做得很好。
887This is the universal codes being used all over the world.这是全世界通用的密码。
888You'll see it on Chinese products, American products,你会看到它在中国产品, 美国产品,
889European products, African products.欧洲产品,非洲产品。
890The easiest to recycle are ones, twos, and fives.最易回收的是一,二,五.
891So one, two, five, good.所以一,二,五,不错。
892Three, seven, not good.三,七,情况不妙.
893And if it's black plastic, you just throw it away,如果它是黑色的塑料, 你就把它扔掉,
894because it's got recycled electronic waste,因为它有回收的电子废物,
895and it's not going to be recycled again.它不会再被回收了
896Now, here's a positive slide.现在,这里是一个积极的幻灯片。
897Finally, so at your level, personal family,最后,在你的层面,个人家庭,
898we can try to reduce unnecessary consumption我们可以尝试减少不必要的消耗
899and unnecessary waste.和不必要的浪费。
900We can avoid all forever chemicals.我们可以永远避免化学物质
901We really need to get PFAS out of our society,我们真的需要让PFAS离开我们的社会,
902because we now know that they can cause disease,因为我们现在知道 他们可以引起疾病,
903and we now know that they're around forever,现在我们知道他们永远在身边,
904virtually forever.几乎永远。
905We need to properly dispose pharmaceuticals,我们需要妥善处置药品,
906spelled correctly.拼写正确。
907We need pollution prevention, cleanup,我们需要污染预防,清理,
908including correct recycling,包括正确的再循环,
909and we have to take political action我们必须采取政治行动
910to insist on safe drinking water.坚持安全饮水.
911Safe drinking water, I believe,我相信,安全饮水,
912is responsibility of our government.是我们政府的责任
913Because we cannot guarantee safe drinking water.因为我们不能保证安全饮水。
914I don't control the reservoirs and aquifers我不控制水库和蓄水层
915and the sources of water for the Beijing和北京的水源
916or the New York City water supply.或纽约市供水。
917The government does that for me.政府这样做是为了我。
918I elect officials to protect me.我选举官员来保护我
919It's part of their function.这是他们的一部分功能。
920So we need to exert political action.因此,我们需要采取政治行动。
921Now, government and industry are not off the hook.现在,政府和工业并没有摆脱困境。
922They are responsible regulation and enforcement他们是负责的监管和执法
923and adherence.和坚持。
924And they can have regulations and enforce themselves他们可以制定条例 执行自己
925if they are responsible.如果他们有责任的话
926Pollution prevention and cleanup,污染预防和清理;
927upgrading wastewater treatment plants,改造废水处理厂,
928because wastewater treatment plants因为废水处理厂
929need advanced treatment processes需要的高级治疗程序
930to process a lot of these chemicals.处理很多这些化学品。
931And they can process a lot of the chemicals,他们可以处理很多化学品,
932but they need advanced processes,但他们需要先进的程序,
933which the older plants don't have.更古老的植物没有它
934Placement and use of landfills.填埋场的放置和使用。
935There are places that are better to put a landfill有些地方最好放垃圾填埋场
936and places that are worse.和那些更糟的地方。
937Some landfills are put in places that are disaster.一些垃圾填埋场被放置在灾难的地方.
938Because the landfill just leeches right into a stream.因为垃圾填埋场只是水蚤 直接进入溪流。
939And green chemistry, oops.和绿色化学,ops。
940Green chemistry, what is green chemistry?绿色化学,绿色化学是什么?
941That is the design of chemical products and processes这就是化学产品和工艺的设计
942that reduce or eliminate the use减少或消除使用
943or generation of hazardous substances.或生成危险物质。
944So green chemistry, the so-called father of green chemistry所以绿色化学,所谓的绿色化学之父
945is a man named Paul Anastas.一个叫保罗·阿纳斯塔斯的人
946He won the Volvo Prize in Environmental Health Sciences他获得了沃尔沃环境卫生科学奖
947about two years ago, three years ago.大约两年前,三年前。
948And that's considered the Nobel Prize这被认为是诺贝尔奖
949for Environmental Science.环境科学。
950And I'm proud to say he's a member of our faculty.我很自豪地说他是我们教职员
951He's at Yale School of Public Health他在耶鲁公共卫生学院
952and has a joint appointment并有联合预约
953with the Yale School of Environment.与耶鲁环境学院.
954And I learned a lot about these issues我学到了很多关于这些问题的知识
955from Paul and readings that he guided me to他从保罗那里降示的经典,以及他引导我的经典,
956when I was dean.当我是院长。
957So what happens is you've got a product chemical发生的事情是,你有一个产品化学
958that helps you with lubrication of equipment in a factory.帮助你润滑设备 在工厂。
959And eventually that chemical ends up in the environment.最后,这种化学物质最终会进入环境。
960Either because it's being used要么是因为有人用它
961and then it dribbles onto the floor and it's cleaned up然后它滑到地板上 清理干净
962or somebody cleans the machine and it's cleaned up或有人清理机器 并清理干净
963or it gets aerated.或者会发热
964And it might be very toxic, toxic to humans,它可能很有毒 对人类有毒
965toxic to animals, toxic to plants, whatever.对动物有毒 对植物有毒 随便什么
966But if a green chemist gets ahold of this and works on it,但是如果一个绿色的化学家 得到这个和它的工作,
967they may be able to develop a product他们也许能够开发产品
968that retains the qualities needed for lubrication保留润滑所需的品质
969but substantially diminishes the toxicity.但却大大降低了毒性。
970That is green chemistry.这是绿色化学。
971And that is a very noble profession这是非常崇高的职业
972because nobody expects us to get rid of chemicals.因为没有人希望我们 摆脱化学物质。
973Chemicals are here.化学品来了
974We don't live our lifestyles without chemicals.我们的生活方式不是没有化学物质的
975But if we can reduce the toxicity of the chemicals we use,但是如果我们能减少我们使用的化学物质的毒性
976that's a win-win situation.那是双赢的局面
977So the field of green chemistry takes these compounds因此,绿色化学领域 取这些化合物
978and changes or manipulates them in experimental ways.以实验方式改变或操纵它们。
979Sometimes you can do computer modeling有时候你可以做电脑模特
980and use AI to estimate whether taking the fluorine off并使用人工智能来估计是否脱氟
981and putting something else on,并穿上别的东西,
982putting on a hydroxy group on,戴上一个羟基组,
983will that change the quality that's favorable这会改变 质量是有利的
984in the chemistry and will that reduce the toxicity?在化学中,并会减少毒性?
985A big part of toxicity is persistence in the environment毒性的一大部分是环境中的持久性
986and you can sometimes put a chemical moiety你有时可以把 化学忧郁症
987that if the compound encounters water如果化合物遇到水
988or encounters some other substance,或者遇到一些其他物质,
989it will cause it to break in half.它会使它分裂成一半。
990But in the use of the product, it retains its strength但是,在使用产品时,它保留了自己的力量
991because it's not in contact with water.因为它不与水接触。
992Stuff like that.像这样的东西。
993Clever, creative chemical strategies.聪明,有创意的化学策略.
994And that's just our school's logo and in front of the school那是我们学校的标志 在学校门口
995and when we're working hard on COVID,当我们努力研究COVID时
996somebody put a little thank you heart.有人会谢谢你的心
997So I like that one.所以我喜欢这个。
998And Xie Xie, thank you for your tip.谢X,谢 tip的提示.
999Thank you.谢谢
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